FGFRL1

Fibroblast growth factor receptor-like 1, also known as FGFRL1, is a human gene.cite web | title = Entrez Gene: FGFRL1 fibroblast growth factor receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53834| accessdate = ]

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summary_text = The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.cite web | title = Entrez Gene: FGFRL1 fibroblast growth factor receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53834| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Wiedemann M, Trueb B |title=Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. |journal=Genomics |volume=69 |issue= 2 |pages= 275–9 |year= 2001 |pmid= 11031111 |doi= 10.1006/geno.2000.6332
*cite journal | author=Kim I, Moon S, Yu K, "et al." |title=A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas(1). |journal=Biochim. Biophys. Acta |volume=1518 |issue= 1-2 |pages= 152–6 |year= 2001 |pmid= 11267671 |doi=
*cite journal | author=Sleeman M, Fraser J, McDonald M, "et al." |title=Identification of a new fibroblast growth factor receptor, FGFR5. |journal=Gene |volume=271 |issue= 2 |pages= 171–82 |year= 2001 |pmid= 11418238 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Trueb B, Zhuang L, Taeschler S, Wiedemann M |title=Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 33857–65 |year= 2003 |pmid= 12813049 |doi= 10.1074/jbc.M300281200
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Antoine M, Wirz W, Tag CG, "et al." |title=Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells. |journal=Growth Factors |volume=23 |issue= 2 |pages= 87–95 |year= 2005 |pmid= 16019430 |doi= 10.1080/08977190500096004
*cite journal | author=Schild C, Trueb B |title=Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors. |journal=Int. J. Mol. Med. |volume=16 |issue= 6 |pages= 1169–73 |year= 2006 |pmid= 16273302 |doi=

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