FAT (gene)

FAT tumor suppressor homolog 1 (Drosophila), also known as FAT, is a human gene.cite web | title = Entrez Gene: FAT FAT tumor suppressor homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2195| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.cite web | title = Entrez Gene: FAT FAT tumor suppressor homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2195| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dunne J, Hanby AM, Poulsom R, "et al." |title=Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule. |journal=Genomics |volume=30 |issue= 2 |pages= 207–23 |year= 1996 |pmid= 8586420 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Matsuyoshi N, Tanaka T, Toda K, Imamura S |title=Identification of novel cadherins expressed in human melanoma cells. |journal=J. Invest. Dermatol. |volume=108 |issue= 6 |pages= 908–13 |year= 1997 |pmid= 9182820 |doi=
*cite journal | author=Matsuyoshi N, Imamura S |title=Multiple cadherins are expressed in human fibroblasts. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 2 |pages= 355–8 |year= 1997 |pmid= 9199196 |doi= 10.1006/bbrc.1997.6707
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Tanoue T, Takeichi M |title=Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. |journal=J. Cell Biol. |volume=165 |issue= 4 |pages= 517–28 |year= 2004 |pmid= 15148305 |doi= 10.1083/jcb.200403006
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Wu Q |title=Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. |journal=Genetics |volume=169 |issue= 4 |pages= 2179–88 |year= 2005 |pmid= 15744052 |doi= 10.1534/genetics.104.037606
*cite journal | author=Magg T, Schreiner D, Solis GP, "et al." |title=Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus. |journal=Exp. Cell Res. |volume=307 |issue= 1 |pages= 100–8 |year= 2005 |pmid= 15922730 |doi= 10.1016/j.yexcr.2005.03.006
*cite journal | author=Blair IP, Chetcuti AF, Badenhop RF, "et al." |title=Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele. |journal=Mol. Psychiatry |volume=11 |issue= 4 |pages= 372–83 |year= 2006 |pmid= 16402135 |doi= 10.1038/sj.mp.4001784
*cite journal | author=Schreiner D, Müller K, Hofer HW |title=The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins. |journal=FEBS Lett. |volume=580 |issue= 22 |pages= 5295–300 |year= 2006 |pmid= 16979624 |doi= 10.1016/j.febslet.2006.08.079
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Nakaya K, Yamagata HD, Arita N, "et al." |title=Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array. |journal=Oncogene |volume=26 |issue= 36 |pages= 5300–8 |year= 2007 |pmid= 17325662 |doi= 10.1038/sj.onc.1210330
*cite journal | author=Braun GS, Kretzler M, Heider T, "et al." |title=Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells. |journal=J. Biol. Chem. |volume=282 |issue= 31 |pages= 22823–33 |year= 2007 |pmid= 17500054 |doi= 10.1074/jbc.M701758200

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