SLURP1

Secreted LY6/PLAUR domain containing 1, also known as SLURP1, is a human gene.cite web | title = Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57152| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.cite web | title = Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57152| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ridge RJ, Sloane NH |title=Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes. |journal=Cytokine |volume=8 |issue= 1 |pages= 1–5 |year= 1996 |pmid= 8742060 |doi= 10.1006/cyto.1996.0001
*cite journal | author=Fischer J, Bouadjar B, Heilig R, "et al." |title=Genetic linkage of Meleda disease to chromosome 8qter. |journal=Eur. J. Hum. Genet. |volume=6 |issue= 6 |pages= 542–7 |year= 1999 |pmid= 9887370 |doi= 10.1038/sj.ejhg.5200254
*cite journal | author=Adermann K, Wattler F, Wattler S, "et al." |title=Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily. |journal=Protein Sci. |volume=8 |issue= 4 |pages= 810–9 |year= 1999 |pmid= 10211827 |doi=
*cite journal | author=Fischer J, Bouadjar B, Heilig R, "et al." |title=Mutations in the gene encoding SLURP-1 in Mal de Meleda. |journal=Hum. Mol. Genet. |volume=10 |issue= 8 |pages= 875–80 |year= 2001 |pmid= 11285253 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Eckl KM, Stevens HP, Lestringant GG, "et al." |title=Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates. |journal=Hum. Genet. |volume=112 |issue= 1 |pages= 50–6 |year= 2003 |pmid= 12483299 |doi= 10.1007/s00439-002-0838-8
*cite journal | author=Marrakchi S, Audebert S, Bouadjar B, "et al." |title=Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda. |journal=J. Invest. Dermatol. |volume=120 |issue= 3 |pages= 351–5 |year= 2003 |pmid= 12603845 |doi= 10.1046/j.1523-1747.2003.12062.x
*cite journal | author=Hu G, Yildirim M, Baysal V, "et al." |title=A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect. |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 967–9 |year= 2003 |pmid= 12787122 |doi= 10.1046/j.1523-1747.2003.12248.x
*cite journal | author=Chimienti F, Hogg RC, Plantard L, "et al." |title=Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. |journal=Hum. Mol. Genet. |volume=12 |issue= 22 |pages= 3017–24 |year= 2004 |pmid= 14506129 |doi= 10.1093/hmg/ddg320
*cite journal | author=Charfeddine C, Mokni M, Ben Mousli R, "et al." |title=A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia. |journal=Br. J. Dermatol. |volume=149 |issue= 6 |pages= 1108–15 |year= 2004 |pmid= 14674887 |doi=
*cite journal | author=Mastrangeli R, Donini S, Kelton CA, "et al." |title=ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda. |journal=European journal of dermatology : EJD |volume=13 |issue= 6 |pages= 560–70 |year= 2004 |pmid= 14721776 |doi=
*cite journal | author=Mokni M, Charfeddine C, Ben Mously R, "et al." |title=Heterozygous manifestations in female carriers of Mal de Meleda. |journal=Clin. Genet. |volume=65 |issue= 3 |pages= 244–6 |year= 2004 |pmid= 14756676 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chao SC, Lai FJ, Yang MH, Lee JY |title=Mal de Meleda in a taiwanese. |journal=J. Formos. Med. Assoc. |volume=104 |issue= 4 |pages= 276–8 |year= 2006 |pmid= 15909066 |doi=
*cite journal | author=Arredondo J, Chernyavsky AI, Webber RJ, Grando SA |title=Biological effects of SLURP-1 on human keratinocytes. |journal=J. Invest. Dermatol. |volume=125 |issue= 6 |pages= 1236–41 |year= 2006 |pmid= 16354194 |doi= 10.1111/j.0022-202X.2005.23973.x
*cite journal | author=Arredondo J, Chernyavsky AI, Grando SA |title=Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells. |journal=Biochem. Pharmacol. |volume=74 |issue= 8 |pages= 1315–9 |year= 2007 |pmid= 17643396 |doi= 10.1016/j.bcp.2007.06.026

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