CDK5RAP2

CDK5 regulatory subunit associated protein 2, also known as CDK5RAP2, is a human gene.cite web | title = Entrez Gene: CDK5RAP2 CDK5 regulatory subunit associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55755| accessdate = ]

PBB_Summary
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summary_text = Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein may also be a substrate of neuronal CDC2-like kinase. Multiple transcript variants exist for this gene, but the full-length nature of only two has been determined.cite web | title = Entrez Gene: CDK5RAP2 CDK5 regulatory subunit associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55755| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Moynihan L, Jackson AP, Roberts E, "et al." |title=A third novel locus for primary autosomal recessive microcephaly maps to chromosome 9q34. |journal=Am. J. Hum. Genet. |volume=66 |issue= 2 |pages= 724–7 |year= 2000 |pmid= 10677332 |doi=
*cite journal | author=Ching YP, Qi Z, Wang JH |title=Cloning of three novel neuronal Cdk5 activator binding proteins. |journal=Gene |volume=242 |issue= 1-2 |pages= 285–94 |year= 2000 |pmid= 10721722 |doi=
*cite journal | author=Wang X, Ching YP, Lam WH, "et al." |title=Identification of a common protein association region in the neuronal Cdk5 activator. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31763–9 |year= 2000 |pmid= 10915792 |doi= 10.1074/jbc.M004358200
*cite journal | author=Nagase T, Kikuno R, Nakayama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi=
*cite journal | author=Ching YP, Pang AS, Lam WH, "et al." |title=Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15237–40 |year= 2002 |pmid= 11882646 |doi= 10.1074/jbc.C200032200
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Andersen JS, Wilkinson CJ, Mayor T, "et al." |title=Proteomic characterization of the human centrosome by protein correlation profiling. |journal=Nature |volume=426 |issue= 6966 |pages= 570–4 |year= 2003 |pmid= 14654843 |doi= 10.1038/nature02166
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Humphray SJ, Oliver K, Hunt AR, "et al." |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Bond J, Roberts E, Springell K, "et al." |title=A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. |journal=Nat. Genet. |volume=37 |issue= 4 |pages= 353–5 |year= 2005 |pmid= 15793586 |doi= 10.1038/ng1539
*cite journal | author=Nousiainen M, Silljé HH, Sauer G, "et al." |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103
*cite journal | author=Evans PD, Vallender EJ, Lahn BT |title=Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ. |journal=Gene |volume=375 |issue= |pages= 75–9 |year= 2006 |pmid= 16631324 |doi= 10.1016/j.gene.2006.02.019
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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