CD200

CD200 (Cluster of Differentiation 200) is a human protein encoded by the gene|CD200 gene.cite web | title = Entrez Gene: CD200 CD200 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4345| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.cite web | title = Entrez Gene: CD200 CD200 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4345| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gorczynski RM |title=Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=49 |issue= 4 |pages= 303–9 |year= 2002 |pmid= 11726033 |doi=
*cite journal | author=Douglas J, Albertson DG, Barclay AN, "et al." |title=RFLP and mapping of human MOX-1 gene on chromosome 3. |journal=Nucleic Acids Res. |volume=16 |issue= 18 |pages= 9067 |year= 1988 |pmid= 2902568 |doi=
*cite journal | author=McCaughan GW, Clark MJ, Barclay AN |title=Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein. |journal=Immunogenetics |volume=25 |issue= 5 |pages= 329–35 |year= 1987 |pmid= 3032785 |doi=
*cite journal | author=Wright GJ, Puklavec MJ, Willis AC, "et al." |title=Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. |journal=Immunity |volume=13 |issue= 2 |pages= 233–42 |year= 2000 |pmid= 10981966 |doi=
*cite journal | author=Hoek RM, Ruuls SR, Murphy CA, "et al." |title=Down-regulation of the macrophage lineage through interaction with OX2 (CD200). |journal=Science |volume=290 |issue= 5497 |pages= 1768–71 |year= 2000 |pmid= 11099416 |doi=
*cite journal | author=Wright GJ, Jones M, Puklavec MJ, "et al." |title=The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. |journal=Immunology |volume=102 |issue= 2 |pages= 173–9 |year= 2001 |pmid= 11260322 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wright GJ, Cherwinski H, Foster-Cuevas M, "et al." |title=Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. |journal=J. Immunol. |volume=171 |issue= 6 |pages= 3034–46 |year= 2003 |pmid= 12960329 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chen DX, Gorczynski RM |title=Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function. |journal=Transplantation |volume=79 |issue= 3 |pages= 282–8 |year= 2005 |pmid= 15699757 |doi=
*cite journal | author=Chen Z, Marsden PA, Gorczynski RM |title=Cloning and characterization of the human CD200 promoter region. |journal=Mol. Immunol. |volume=43 |issue= 6 |pages= 579–87 |year= 2006 |pmid= 15955564 |doi= 10.1016/j.molimm.2005.04.014
*cite journal | author=Shiratori I, Yamaguchi M, Suzukawa M, "et al." |title=Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. |journal=J. Immunol. |volume=175 |issue= 7 |pages= 4441–9 |year= 2005 |pmid= 16177086 |doi=
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Matsue H |title=CD 200-mediated regulation of skin immunity. |journal=J. Invest. Dermatol. |volume=125 |issue= 6 |pages= x-xi |year= 2006 |pmid= 16354172 |doi= 10.1111/j.0022-202X.2005.23978.x

External links

*

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