Pancreatic hormone

Pancreatic hormone

Pfam_box
Symbol = Hormone_3
Name = Pancreatic hormone peptide


width =
caption =
Pfam= PF00159
InterPro= IPR001955
SMART=
PROSITE = PDOC00238
SCOP = 1ppt
TCDB =
OPM family=
OPM protein= 1icy
PDB=PDB3|1k8vA:1-39 PDB3|1ruuA:1-36 PDB3|1ru5A:1-36PDB3|1qbfA:1-36 PDB3|1ron :29-64 PDB3|1qfaA:52-64PDB3|1r9nF:29-38 PDB3|1icyA:10-45 PDB3|1f8pA:10-45PDB3|1fvnA:10-45 PDB3|1ljvA:30-65 PDB3|1v1dA:30-60PDB3|1bba :30-65 PDB3|2bf9A:1-35 PDB3|1ppt :1-36

Pancreatic hormones (PP)cite journal |author=Humbel RE, Blundell TL |title=Hormone families:pancreatic hormones and homologous growth factors |journal=Nature |volume=287 |issue=5785 |pages=781–787 |year=1980 |pmid=6107857 |doi=10.1038/287781a0] are peptides synthesized in pancreatic islets of Langherhans, which acts as a regulator of pancreatic and gastrointestinal functions.

The hormone is produced as a larger propeptide, which is enzymatically cleaved to yield the mature active peptide: this is 36 amino acids in lengthcite journal |author=Martin J, Allen J, Novotny J, Heinrich G |title=Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue=8 |pages=2532–2536 |year=1987 |pmid=3031687 |doi=10.1073/pnas.84.8.2532] and has an amidated C terminuscite journal |author=Mutt V, Sillard R, Agerberth B, Jornvall H |title=Sheep neuropeptide Y. A third structural type of a highly conserved peptide |journal=FEBS Lett. |volume=258 |issue=2 |pages=263–265 |year=1989 |pmid=2599092 |doi=10.1016/0014-5793(89)81669-2] . The hormone has a globular structure, residues 2-8 forming a left-handed poly-proline-II-like helix, residues 9-13 a beta turn, and 14-32 an alpha-helix,held close to the first helix by hydrophobic interactions. Unlike glucagon, another peptide hormone, the structure of pancreatic peptide is preserved in aqueous solutioncite journal |author=Conlon JM, Thim L, Bjenning C, Moon TW, Youson JH |title=Neuropeptide Y-related peptides from the pancreas of a teleostean (eel), holostean (bowfin) and elasmobranch (skate) fish |journal=Peptides |volume=12 |issue=2 |pages=221–226 |year=1991 |pmid=2067973 |doi=10.1016/0196-9781(91)90003-8] . Both N and C termini are required for activity: receptor binding and activation functions may reside in the N and C termini respectivelycite journal |author=Martin J, Allen J, Novotny J, Heinrich G |title=Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue=8 |pages=2532–2536 |year=1987 |pmid=3031687 |doi=10.1073/pnas.84.8.2532] .

ubfamilies

*Pancreatic hormone subtype InterPro|IPR015480
*Peptide YY InterPro|IPR015481

Human proteins containing this domain

NPY; PPY; PYY;

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • pancreatic juice — n a clear alkaline secretion of pancreatic enzymes (as trypsin and lipase) that flows into the duodenum and acts on food already acted on by the gastric juice and saliva * * * the digestive juice secreted by the pancreas. Its production is… …   Medical dictionary

  • Hormone, secretin — Hormone made by glands in the small intestine that stimulates pancreatic secretion. The word "hormone" was coined by the English physiologists Wm. M. Bayliss and Ernest H. Starling in connection with their discovery of secretin, the… …   Medical dictionary

  • hormone — hormonal, hormonic /hawr mon ik, moh nik/, adj. /hawr mohn/, n. 1. Biochem. any of various internally secreted compounds, as insulin or thyroxine, formed in endocrine glands, that affect the functions of specifically receptive organs or tissues… …   Universalium

  • Hormone — A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. Many hormones are secreted by specialized glands such as the thyroid gland. Hormones are essential for every activity of daily living,… …   Medical dictionary

  • pancreatic cancer — Malignant tumour of the pancreas. Risk factors include smoking, a diet high in fat, exposure to certain industrial products, and diseases such as diabetes and chronic pancreatitis. Pancreatic cancer is more common in men. Symptoms often do not… …   Universalium

  • Pancreatic disease — ICD10|Q|45|3|q|38 ICD9 = ICD9|577, ICD9|751.7 ICDO = OMIM = MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = D010182 Pancreatic diseases include:PancreatitisPancreatitis is inflammation of the pancreas. There are two forms of pancreatitis …   Wikipedia

  • pancreatic polypeptide — a hormone released from the delta cells of the islets of Langerhans of the pancreas in response to protein in the small intestine. Its actions are to inhibit pancreatic bicarbonate and protein enzyme secretion and to relax the gall bladder. It… …   Medical dictionary

  • pancreatic juice — the digestive juice secreted by the pancreas. Its production is stimulated by hormones secreted by the duodenum, which in turn is stimulated by contact with food from the stomach. If the duodenum produces the hormone secretin the pancreatic juice …   The new mediacal dictionary

  • hormone — Synonyms and related words: Allen Doisy hormone, adjuvant, adrenosterone, androgen, androsterone, autacoid, bile, carminative, chalone, cholecystokinin, chondrotrophic hormone, corticosterone, counterirritant, dehydrocorticosterone, digestive… …   Moby Thesaurus

  • pancreatic polypeptide — a hormone released from the D cells of the islets of Langerhans of the pancreas in response to protein in the small intestine. Its actions are to inhibit pancreatic bicarbonate and protein enzyme secretion and to relax the gall bladder. It… …   The new mediacal dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”