LAG3

Lymphocyte-activation gene 3, also known as LAG3, is a human gene.cite web | title = Entrez Gene: LAG3 lymphocyte-activation gene 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3902| accessdate = ] LAG3 has also recently been designated CD223 (cluster of differentiation 223).

PBB_Summary
section_title =
summary_text = Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.cite web | title = Entrez Gene: LAG3 lymphocyte-activation gene 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3902| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Triebel F |title=LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination. |journal=Trends Immunol. |volume=24 |issue= 12 |pages= 619–22 |year= 2004 |pmid= 14644131 |doi=
*cite journal | author=Baixeras E, Huard B, Miossec C, "et al." |title=Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. |journal=J. Exp. Med. |volume=176 |issue= 2 |pages= 327–37 |year= 1992 |pmid= 1380059 |doi=
*cite journal | author=Triebel F, Jitsukawa S, Baixeras E, "et al." |title=LAG-3, a novel lymphocyte activation gene closely related to CD4. |journal=J. Exp. Med. |volume=171 |issue= 5 |pages= 1393–405 |year= 1990 |pmid= 1692078 |doi=
*cite journal | author=Blum MD, Wong GT, Higgins KM, "et al." |title=Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer. |journal=J. Exp. Med. |volume=177 |issue= 5 |pages= 1343–58 |year= 1993 |pmid= 8097522 |doi=
*cite journal | author=Huard B, Mastrangeli R, Prigent P, "et al." |title=Characterization of the major histocompatibility complex class II binding site on LAG-3 protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5744–9 |year= 1997 |pmid= 9159144 |doi=
*cite journal | author=Bruniquel D, Borie N, Triebel F |title=Genomic organization of the human LAG-3/CD4 locus. |journal=Immunogenetics |volume=47 |issue= 1 |pages= 96–8 |year= 1998 |pmid= 9382927 |doi=
*cite journal | author=Bruniquel D, Borie N, Hannier S, Triebel F |title=Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II. |journal=Immunogenetics |volume=48 |issue= 2 |pages= 116–24 |year= 1998 |pmid= 9634475 |doi=
*cite journal | author=Hannier S, Tournier M, Bismuth G, Triebel F |title=CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling. |journal=J. Immunol. |volume=161 |issue= 8 |pages= 4058–65 |year= 1998 |pmid= 9780176 |doi=
*cite journal | author=Hannier S, Triebel F |title=The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes. |journal=Int. Immunol. |volume=11 |issue= 11 |pages= 1745–52 |year= 1999 |pmid= 10545478 |doi=
*cite journal | author=Iouzalen N, Andreae S, Hannier S, Triebel F |title=LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway. |journal=Eur. J. Immunol. |volume=31 |issue= 10 |pages= 2885–91 |year= 2001 |pmid= 11592063 |doi=
*cite journal | author=Andreae S, Piras F, Burdin N, Triebel F |title=Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223). |journal=J. Immunol. |volume=168 |issue= 8 |pages= 3874–80 |year= 2002 |pmid= 11937541 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Andreae S, Buisson S, Triebel F |title=MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223). |journal=Blood |volume=102 |issue= 6 |pages= 2130–7 |year= 2003 |pmid= 12775570 |doi= 10.1182/blood-2003-01-0273
*cite journal | author=Cai XF, Tao Z, Yan ZQ, "et al." |title=Molecular cloning, characterisation and tissue-specific expression of human LAG3, a member of the novel Lag1 protein family. |journal=DNA Seq. |volume=14 |issue= 2 |pages= 79–86 |year= 2004 |pmid= 12825348 |doi=
*cite journal | author=Gandhi MK, Lambley E, Duraiswamy J, "et al." |title=Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients. |journal=Blood |volume=108 |issue= 7 |pages= 2280–9 |year= 2006 |pmid= 16757686 |doi= 10.1182/blood-2006-04-015164
*cite journal | author=Lundmark F, Harbo HF, Celius EG, "et al." |title=Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations. |journal=J. Neuroimmunol. |volume=180 |issue= 1-2 |pages= 193–8 |year= 2007 |pmid= 17020785 |doi= 10.1016/j.jneuroim.2006.08.009

External links

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