FMOD (gene)

Fibromodulin, also known as FMOD, is a human gene.cite web | title = Entrez Gene: FMOD fibromodulin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2331| accessdate = ]

PBB_Summary
section_title =
summary_text = Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix.cite web | title = Entrez Gene: FMOD fibromodulin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2331| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Roughley PJ, Lee ER |title=Cartilage proteoglycans: structure and potential functions. |journal=Microsc. Res. Tech. |volume=28 |issue= 5 |pages= 385–97 |year= 1994 |pmid= 7919526 |doi= 10.1002/jemt.1070280505
*cite journal | author=Sztrolovics R, Chen XN, Grover J, "et al." |title=Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence. |journal=Genomics |volume=23 |issue= 3 |pages= 715–7 |year= 1995 |pmid= 7851907 |doi= 10.1006/geno.1994.1567
*cite journal | author=Hildebrand A, Romarís M, Rasmussen LM, "et al." |title=Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. |journal=Biochem. J. |volume=302 ( Pt 2) |issue= |pages= 527–34 |year= 1994 |pmid= 8093006 |doi=
*cite journal | author=Antonsson P, Heinegård D, Oldberg A |title=Structure and deduced amino acid sequence of the human fibromodulin gene. |journal=Biochim. Biophys. Acta |volume=1174 |issue= 2 |pages= 204–6 |year= 1993 |pmid= 8357838 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Westergren-Thorsson G, Norman M, Björnsson S, "et al." |title=Differential expressions of mRNA for proteoglycans, collagens and transforming growth factor-beta in the human cervix during pregnancy and involution. |journal=Biochim. Biophys. Acta |volume=1406 |issue= 2 |pages= 203–13 |year= 1998 |pmid= 9573366 |doi=
*cite journal | author=Font B, Eichenberger D, Goldschmidt D, "et al." |title=Structural requirements for fibromodulin binding to collagen and the control of type I collagen fibrillogenesis--critical roles for disulphide bonding and the C-terminal region. |journal=Eur. J. Biochem. |volume=254 |issue= 3 |pages= 580–7 |year= 1998 |pmid= 9688269 |doi=
*cite journal | author=Schaefer L, Gröne HJ, Raslik I, "et al." |title=Small proteoglycans of normal adult human kidney: distinct expression patterns of decorin, biglycan, fibromodulin, and lumican. |journal=Kidney Int. |volume=58 |issue= 4 |pages= 1557–68 |year= 2000 |pmid= 11012890 |doi= 10.1046/j.1523-1755.2000.00317.x
*cite journal | author=Gori F, Schipani E, Demay MB |title=Fibromodulin is expressed by both chondrocytes and osteoblasts during fetal bone development. |journal=J. Cell. Biochem. |volume=82 |issue= 1 |pages= 46–57 |year= 2001 |pmid= 11400162 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Mayr C, Bund D, Schlee M, "et al." |title=Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL), which allows expansion of specific CD8+ autologous T lymphocytes. |journal=Blood |volume=105 |issue= 4 |pages= 1566–73 |year= 2005 |pmid= 15471955 |doi= 10.1182/blood-2004-04-1233
*cite journal | author=Mikaelsson E, Danesh-Manesh AH, Lüppert A, "et al." |title=Fibromodulin, an extracellular matrix protein: characterization of its unique gene and protein expression in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. |journal=Blood |volume=105 |issue= 12 |pages= 4828–35 |year= 2005 |pmid= 15741214 |doi= 10.1182/blood-2004-10-3941
*cite journal | author=Sjöberg A, Onnerfjord P, Mörgelin M, "et al." |title=The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. |journal=J. Biol. Chem. |volume=280 |issue= 37 |pages= 32301–8 |year= 2005 |pmid= 16046396 |doi= 10.1074/jbc.M504828200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Sjöberg AP, Trouw LA, Clark SJ, "et al." |title=The factor H variant associated with age-related macular degeneration (His-384) and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells. |journal=J. Biol. Chem. |volume=282 |issue= 15 |pages= 10894–900 |year= 2007 |pmid= 17293598 |doi= 10.1074/jbc.M610256200
*cite journal | author=Kalamajski S, Oldberg A |title=Fibromodulin binds collagen type I via Glu-353 and Lys-355 in leucine-rich repeat 11. |journal=J. Biol. Chem. |volume=282 |issue= 37 |pages= 26740–5 |year= 2007 |pmid= 17623650 |doi= 10.1074/jbc.M704026200

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes