PRKAB2

Protein kinase, AMP-activated, beta 2 non-catalytic subunit, also known as PRKAB2, is a human gene.cite web | title = Entrez Gene: PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5565| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.cite web | title = Entrez Gene: PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5565| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stapleton D, Mitchelhill KI, Gao G, "et al." |title=Mammalian AMP-activated protein kinase subfamily. |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 611–4 |year= 1996 |pmid= 8557660 |doi=
*cite journal | author=Gao G, Fernandez CS, Stapleton D, "et al." |title=Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8675–81 |year= 1996 |pmid= 8621499 |doi=
*cite journal | author=Woods A, Cheung PC, Smith FC, "et al." |title=Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10282–90 |year= 1996 |pmid= 8626596 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Stapleton D, Woollatt E, Mitchelhill KI, "et al." |title=AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location. |journal=FEBS Lett. |volume=409 |issue= 3 |pages= 452–6 |year= 1997 |pmid= 9224708 |doi=
*cite journal | author=Thornton C, Snowden MA, Carling D |title=Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. |journal=J. Biol. Chem. |volume=273 |issue= 20 |pages= 12443–50 |year= 1998 |pmid= 9575201 |doi=
*cite journal | author=Cheung PC, Salt IP, Davies SP, "et al." |title=Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. |journal=Biochem. J. |volume=346 Pt 3 |issue= |pages= 659–69 |year= 2000 |pmid= 10698692 |doi=
*cite journal | author=Xu XR, Huang J, Xu ZG, "et al." |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398
*cite journal | author=Park SH, Paulsen SR, Gammon SR, "et al." |title=Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle. |journal=J. Appl. Physiol. |volume=93 |issue= 6 |pages= 2081–8 |year= 2003 |pmid= 12433937 |doi= 10.1152/japplphysiol.00504.2002
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Prochazka M, Farook VS, Ossowski V, "et al." |title=Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians. |journal=Mol. Cell. Probes |volume=16 |issue= 6 |pages= 421–7 |year= 2003 |pmid= 12490143 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Minokoshi Y, Alquier T, Furukawa N, "et al." |title=AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. |journal=Nature |volume=428 |issue= 6982 |pages= 569–74 |year= 2004 |pmid= 15058305 |doi= 10.1038/nature02440
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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