LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae), also known as LSM4, is a human gene.cite web | title = Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)| url =| accessdate = ]

section_title =
summary_text = Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. [supplied by OMIM] cite web | title = Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Singer J, Roberts-Ems J, Luthardt FW, Riggs AD |title=Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit. |journal=Nucleic Acids Res. |volume=7 |issue= 8 |pages= 2369–85 |year= 1980 |pmid= 523320 |doi=
*cite journal | author=Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B |title=Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3451–62 |year= 1999 |pmid= 10369684 |doi= 10.1093/emboj/18.12.3451
*cite journal | author=Achsel T, Brahms H, Kastner B, "et al." |title=A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5789–802 |year= 1999 |pmid= 10523320 |doi= 10.1093/emboj/18.20.5789
*cite journal | author=Friesen WJ, Dreyfuss G |title=Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN). |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26370–5 |year= 2000 |pmid= 10851237 |doi= 10.1074/jbc.M003299200
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Eystathioy T, Peebles CL, Hamel JC, "et al." |title=Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera. |journal=Arthritis Rheum. |volume=46 |issue= 3 |pages= 726–34 |year= 2002 |pmid= 11920408 |doi= 10.1002/art.10220
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T |title=The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. |journal=RNA |volume=8 |issue= 12 |pages= 1489–501 |year= 2003 |pmid= 12515382 |doi=
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fürst J, Schedlbauer A, Gandini R, "et al." |title=ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4. |journal=J. Biol. Chem. |volume=280 |issue= 35 |pages= 31276–82 |year= 2005 |pmid= 15905169 |doi= 10.1074/jbc.M500541200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Yang ZQ, Streicher KL, Ray ME, "et al." |title=Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11632–43 |year= 2007 |pmid= 17178857 |doi= 10.1158/0008-5472.CAN-06-2946
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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