ARFGEF2

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited), also known as ARFGEF2, is a human gene.cite web | title = Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10564| accessdate = ]

PBB_Summary
section_title =
summary_text = ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.cite web | title = Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10564| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Togawa A, Morinaga N, Ogasawara M, "et al." |title=Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12308–15 |year= 1999 |pmid= 10212200 |doi=
*cite journal | author=Yamaji R, Adamik R, Takeda K, "et al." |title=Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2567–72 |year= 2000 |pmid= 10716990 |doi=
*cite journal | author=Kamei Y, Takeda Y, Teramoto K, "et al." |title=Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. |journal=Genomics |volume=69 |issue= 1 |pages= 113–9 |year= 2001 |pmid= 11013081 |doi= 10.1006/geno.2000.6310
*cite journal | author=Pacheco-Rodriguez G, Moss J, Vaughan M |title=BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors. |journal=Meth. Enzymol. |volume=345 |issue= |pages= 397–404 |year= 2002 |pmid= 11665623 |doi=
*cite journal | author=Shinotsuka C, Yoshida Y, Kawamoto K, "et al." |title=Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9468–73 |year= 2002 |pmid= 11777925 |doi= 10.1074/jbc.M112427200
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Shinotsuka C, Waguri S, Wakasugi M, "et al." |title=Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 2 |pages= 254–60 |year= 2002 |pmid= 12051703 |doi= 10.1016/S0006-291X(02)00456-4
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Li H, Adamik R, Pacheco-Rodriguez G, "et al." |title=Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 4 |pages= 1627–32 |year= 2003 |pmid= 12571360 |doi= 10.1073/pnas.0337678100
*cite journal | author=Sheen VL, Ganesh VS, Topcu M, "et al." |title=Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 69–76 |year= 2004 |pmid= 14647276 |doi= 10.1038/ng1276
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Xu KF, Shen X, Li H, "et al." |title=Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 8 |pages= 2784–9 |year= 2005 |pmid= 15705715 |doi= 10.1073/pnas.0409871102
*cite journal | author=Lu J, Tiao G, Folkerth R, "et al." |title=Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia. |journal=J. Comp. Neurol. |volume=494 |issue= 3 |pages= 476–84 |year= 2006 |pmid= 16320251 |doi= 10.1002/cne.20806
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Islam A, Shen X, Hiroi T, "et al." |title=The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles. |journal=J. Biol. Chem. |volume=282 |issue= 13 |pages= 9591–9 |year= 2007 |pmid= 17276987 |doi= 10.1074/jbc.M607122200
*cite journal | author=Kuroda F, Moss J, Vaughan M |title=Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 9 |pages= 3201–6 |year= 2007 |pmid= 17360629 |doi= 10.1073/pnas.0611696104

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