CENPJ

Centromere protein J, also known as CENPJ, is a human gene.cite web | title = Entrez Gene: CENPJ centromere protein J| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55835| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation.cite web | title = Entrez Gene: CENPJ centromere protein J| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55835| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Hung LY, Tang CJ, Tang TK |title=Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex. |journal=Mol. Cell. Biol. |volume=20 |issue= 20 |pages= 7813–25 |year= 2000 |pmid= 11003675 |doi=
*cite journal | author=Iouzalen N, Andreae S, Hannier S, Triebel F |title=LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway. |journal=Eur. J. Immunol. |volume=31 |issue= 10 |pages= 2885–91 |year= 2001 |pmid= 11592063 |doi=
*cite journal | author=Tchernev VT, Mansfield TA, Giot L, "et al." |title=The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. |journal=Mol. Med. |volume=8 |issue= 1 |pages= 56–64 |year= 2002 |pmid= 11984006 |doi=
*cite journal | author=Peng B, Sutherland KD, Sum EY, "et al." |title=CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity. |journal=Mol. Endocrinol. |volume=16 |issue= 9 |pages= 2019–33 |year= 2003 |pmid= 12198240 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Leal GF, Roberts E, Silva EO, "et al." |title=A novel locus for autosomal recessive primary microcephaly (MCPH6) maps to 13q12.2. |journal=J. Med. Genet. |volume=40 |issue= 7 |pages= 540–2 |year= 2003 |pmid= 12843329 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hung LY, Chen HL, Chang CW, "et al." |title=Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly. |journal=Mol. Biol. Cell |volume=15 |issue= 6 |pages= 2697–706 |year= 2004 |pmid= 15047868 |doi= 10.1091/mbc.E04-02-0121
*cite journal | author=Dunham A, Matthews LH, Burton J, "et al." |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Koyanagi M, Hijikata M, Watashi K, "et al." |title=Centrosomal P4.1-associated protein is a new member of transcriptional coactivators for nuclear factor-kappaB. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12430–7 |year= 2005 |pmid= 15687488 |doi= 10.1074/jbc.M410420200
*cite journal | author=Bond J, Roberts E, Springell K, "et al." |title=A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. |journal=Nat. Genet. |volume=37 |issue= 4 |pages= 353–5 |year= 2005 |pmid= 15793586 |doi= 10.1038/ng1539
*cite journal | author=Cho JH, Chang CJ, Chen CY, Tang TK |title=Depletion of CPAP by RNAi disrupts centrosome integrity and induces multipolar spindles. |journal=Biochem. Biophys. Res. Commun. |volume=339 |issue= 3 |pages= 742–7 |year= 2006 |pmid= 16316625 |doi= 10.1016/j.bbrc.2005.11.074
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Chen CY, Olayioye MA, Lindeman GJ, Tang TK |title=CPAP interacts with 14-3-3 in a cell cycle-dependent manner. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 4 |pages= 1203–10 |year= 2006 |pmid= 16516142 |doi= 10.1016/j.bbrc.2006.02.089
*cite journal | author=Evans PD, Vallender EJ, Lahn BT |title=Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ. |journal=Gene |volume=375 |issue= |pages= 75–9 |year= 2006 |pmid= 16631324 |doi= 10.1016/j.gene.2006.02.019
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Gul A, Hassan MJ, Hussain S, "et al." |title=A novel deletion mutation in CENPJ gene in a Pakistani family with autosomal recessive primary microcephaly. |journal=J. Hum. Genet. |volume=51 |issue= 9 |pages= 760–4 |year= 2006 |pmid= 16900296 |doi= 10.1007/s10038-006-0017-1

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