RPL7

Ribosomal protein L7, also known as RPL7, is a human gene.cite web | title = Entrez Gene: RPL7 ribosomal protein L7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6129| accessdate = ]

PBB_Summary
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summary_text = Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.cite web | title = Entrez Gene: RPL7 ribosomal protein L7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6129| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wool IG, Chan YL, Glück A |title=Structure and evolution of mammalian ribosomal proteins. |journal=Biochem. Cell Biol. |volume=73 |issue= 11-12 |pages= 933–47 |year= 1996 |pmid= 8722009 |doi=
*cite journal | author=von Mikecz A, Hemmerich P, Peter HH, Krawinkel U |title=Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease. |journal=Immunobiology |volume=192 |issue= 1-2 |pages= 137–54 |year= 1995 |pmid= 7750987 |doi=
*cite journal | author=Neumann F, Hemmerich P, von Mikecz A, "et al." |title=Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells. |journal=Nucleic Acids Res. |volume=23 |issue= 2 |pages= 195–202 |year= 1995 |pmid= 7862521 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Seshadri T, Uzman JA, Oshima J, Campisi J |title=Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene. |journal=J. Biol. Chem. |volume=268 |issue= 25 |pages= 18474–80 |year= 1993 |pmid= 8360149 |doi=
*cite journal | author=Hemmerich P, von Mikecz A, Neumann F, "et al." |title=Structural and functional properties of ribosomal protein L7 from humans and rodents. |journal=Nucleic Acids Res. |volume=21 |issue= 2 |pages= 223–31 |year= 1993 |pmid= 8441630 |doi=
*cite journal | author=Witte S, Krawinkel U |title=Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22243–7 |year= 1997 |pmid= 9268371 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kenmochi N, Kawaguchi T, Rozen S, "et al." |title=A map of 75 human ribosomal protein genes. |journal=Genome Res. |volume=8 |issue= 5 |pages= 509–23 |year= 1998 |pmid= 9582194 |doi=
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Brezillon S, Lannoy V, Franssen JD, "et al." |title=Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 776–83 |year= 2003 |pmid= 12401809 |doi= 10.1074/jbc.M206396200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kasai H, Nadano D, Hidaka E, "et al." |title=Differential expression of ribosomal proteins in human normal and neoplastic colorectum. |journal=J. Histochem. Cytochem. |volume=51 |issue= 5 |pages= 567–74 |year= 2003 |pmid= 12704204 |doi=
*cite journal | author=Odintsova TI, Müller EC, Ivanov AV, "et al." |title=Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. |journal=J. Protein Chem. |volume=22 |issue= 3 |pages= 249–58 |year= 2004 |pmid= 12962325 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207
*cite journal | author=Ko JR, Wu JY, Kirby R, "et al." |title=Mapping the essential structures of human ribosomal protein L7 for nuclear entry, ribosome assembly and function. |journal=FEBS Lett. |volume=580 |issue= 16 |pages= 3804–10 |year= 2006 |pmid= 16797011 |doi= 10.1016/j.febslet.2006.05.073
*cite journal | author=Wu WC, Liu HW, Lin A |title=Human ribosomal protein L7 displays an ER binding property and is involved in ribosome-ER association. |journal=FEBS Lett. |volume=581 |issue= 4 |pages= 651–7 |year= 2007 |pmid= 17258209 |doi= 10.1016/j.febslet.2007.01.023

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