NOL1

NOL1
NOP2 nucleolar protein homolog (yeast)
Identifiers
Symbols NOP2; MGC117384; MGC149287; MGC149288; NOL1; NOP120; NSUN1; p120
External IDs OMIM164031 MGI107891 HomoloGene6817 GeneCards: NOP2 Gene
RNA expression pattern
PBB GE NOL1 214427 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4839 110109
Ensembl ENSG00000111641 ENSMUSG00000038279
UniProt P46087 n/a
RefSeq (mRNA) NM_001033714.1 NM_138747.2
RefSeq (protein) NP_001028886.1 NP_620086.2
Location (UCSC) Chr 12:
6.67 – 6.68 Mb
Chr 6:
125.08 – 125.09 Mb
PubMed search [1] [2]

Putative ribosomal RNA methyltransferase NOP2 is an enzyme that in humans is encoded by the NOP2 gene.[1][1][2]

The protein encoded by this gene is a nucleolar antigen expressed in proliferating cells. It is not detectable in non-proliferating normal tissue but is detectable in many human tumors.[3]

Overexpression of p120 leads to malignant transformation of 3T3 cells while treatment with antisense p120 mRNA causes the transformed cells to revert to their original non-malignant phenotype.[4]

The p120 protein displays a dramatic increase in expression at the G1/S transition suggesting that p120 regulates the cell cycle and nucleolar activity that is required for cell proliferation.[5]

Interactions

NOL1 has been shown to interact with MCRS1.[6]

References

  1. ^ a b Baens M, Chaffanet M, Aerssens J, Cassiman JJ, Marynen P (October 1994). "Assignment of the gene for the human proliferating cell nucleolar protein P120 (NOL1) to chromosome 12p13 by fluorescence in situ hybridization and polymerase chain reaction with somatic cell hybrids". Genomics 21 (1): 296–7. doi:10.1006/geno.1994.1267. PMID 8088812. 
  2. ^ "Entrez Gene: NOL1 nucleolar protein 1, 120kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4839. 
  3. ^ Freeman JW, Busch RK, Gyorkey F, Gyorkey P, Ross BE, Busch H (1 March 1988). "Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase". Cancer Res. 48 (5): 1244–51. PMID 3422591. http://cancerres.aacrjournals.org/cgi/content/abstract/48/5/1244. 
  4. ^ Perlaky L, Valdez BC, Busch RK, Larson RG, Jhiang SM, Zhang WW, Brattain M, Busch H (January 1992). "Increased growth of NIH/3T3 cells by transfection with human p120 complementary DNA and inhibition by a p120 antisense construct". Cancer Res. 52 (2): 428–36. PMID 1728415. http://cancerres.aacrjournals.org/cgi/content/abstract/52/2/428. 
  5. ^ Fonagy A, Swiderski C, Wilson A, Bolton W, Kenyon N, Freeman JW (January 1993). "Cell cycle regulated expression of nucleolar antigen P120 in normal and transformed human fibroblasts". J. Cell. Physiol. 154 (1): 16–27. doi:10.1002/jcp.1041540104. PMID 8419402. 
  6. ^ Ren, Y; Busch R K, Perlaky L, Busch H (May. 1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120". Eur. J. Biochem. (GERMANY) 253 (3): 734–42. doi:10.1046/j.1432-1327.1998.2530734.x. ISSN 0014-2956. PMID 9654073. 

Further reading




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