- ST7
Suppression of tumorigenicity 7, also known as ST7, is a human
gene .cite web | title = Entrez Gene: ST7 suppression of tumorigenicity 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7982| accessdate = ]PBB_Summary
section_title =
summary_text = The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described.cite web | title = Entrez Gene: ST7 suppression of tumorigenicity 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7982| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Zenklusen JC, Weitzel JN, Ball HG, Conti CJ |title=Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene. |journal=Oncogene |volume=11 |issue= 2 |pages= 359–63 |year= 1995 |pmid= 7624150 |doi=
*cite journal | author=Zenklusen JC, Thompson JC, Troncoso P, "et al." |title=Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1. |journal=Cancer Res. |volume=54 |issue= 24 |pages= 6370–3 |year= 1995 |pmid= 7987830 |doi=
*cite journal | author=Zenklusen JC, Bièche I, Lidereau R, Conti CJ |title=(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 25 |pages= 12155–8 |year= 1995 |pmid= 7991599 |doi=
*cite journal | author=Ogata T, Ayusawa D, Namba M, "et al." |title=Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6036–43 |year= 1993 |pmid= 8105370 |doi=
*cite journal | author=Zenklusen JC, Rodriguez LV, LaCava M, "et al." |title=Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene. |journal=Genome Res. |volume=6 |issue= 11 |pages= 1070–6 |year= 1997 |pmid= 8938430 |doi=
*cite journal | author=Folstein SE, Mankoski RE |title=Chromosome 7q: where autism meets language disorder? |journal=Am. J. Hum. Genet. |volume=67 |issue= 2 |pages= 278–81 |year= 2000 |pmid= 10889044 |doi=
*cite journal | author=Vincent JB, Herbrick JA, Gurling HM, "et al." |title=Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual. |journal=Am. J. Hum. Genet. |volume=67 |issue= 2 |pages= 510–4 |year= 2000 |pmid= 10889047 |doi=
*cite journal | author=Zenklusen JC, Conti CJ, Green ED |title=Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. |journal=Nat. Genet. |volume=27 |issue= 4 |pages= 392–8 |year= 2001 |pmid= 11279520 |doi= 10.1038/86891
*cite journal | author=Brown VL, Proby CM, Barnes DM, Kelsell DP |title=Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours. |journal=Br. J. Cancer |volume=87 |issue= 2 |pages= 208–11 |year= 2002 |pmid= 12107844 |doi= 10.1038/sj.bjc.6600418
*cite journal | author=Vincent JB, Petek E, Thevarkunnel S, "et al." |title=The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. |journal=Genomics |volume=80 |issue= 3 |pages= 283–94 |year= 2003 |pmid= 12213198 |doi=
*cite journal | author=Dong SM, Sidransky D |title=Absence of ST7 gene alterations in human cancer. |journal=Clin. Cancer Res. |volume=8 |issue= 9 |pages= 2939–41 |year= 2002 |pmid= 12231539 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang S, Mori Y, Sato F, "et al." |title=An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma. |journal=Oncogene |volume=22 |issue= 3 |pages= 467–70 |year= 2003 |pmid= 12545169 |doi= 10.1038/sj.onc.1206125
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Battle MA, Maher VM, McCormick JJ |title=ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. |journal=Biochemistry |volume=42 |issue= 24 |pages= 7270–82 |year= 2003 |pmid= 12809483 |doi= 10.1021/bi034081y
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Sivasundaram K, Suzuki H, Seto M, Hosokawa Y |title=Mutational analysis of the ST7 gene in human myeloid tumor cell lines. |journal=Oncol. Rep. |volume=10 |issue= 6 |pages= 1737–9 |year= 2004 |pmid= 14534688 |doi=
*cite journal | author=Lu C, Xu HM, Ren Q, "et al." |title=Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC. |journal=World J. Gastroenterol. |volume=9 |issue= 12 |pages= 2662–5 |year= 2004 |pmid= 14669308 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Liu J, Gough J, Rost B |title=Distinguishing protein-coding from non-coding RNAs through support vector machines. |journal=PLoS Genet. |volume=2 |issue= 4 |pages= e29 |year= 2006 |pmid= 16683024 |doi= 10.1371/journal.pgen.0020029PBB_Controls
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