GPX2 (gene)

Glutathione peroxidase 2 (gastrointestinal), also known as GPX2, is a human gene.cite web | title = Entrez Gene: GPX2 glutathione peroxidase 2 (gastrointestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2877| accessdate = ]

PBB_Summary
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summary_text = This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract.cite web | title = Entrez Gene: GPX2 glutathione peroxidase 2 (gastrointestinal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2877| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Akasaka M, Mizoguchi J, Takahashi K |title=A human cDNA sequence of a novel glutathione peroxidase-related protein. |journal=Nucleic Acids Res. |volume=18 |issue= 15 |pages= 4619 |year= 1990 |pmid= 2388849 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Chu FF |title=The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 2 |pages= 96–8 |year= 1994 |pmid= 8287691 |doi=
*cite journal | author=Chu FF, Doroshow JH, Esworthy RS |title=Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2571–6 |year= 1993 |pmid= 8428933 |doi=
*cite journal | author=Chu FF, Rohan de Silva HA, Esworthy RS, "et al." |title=Polymorphism and chromosomal localization of the GI-form of human glutathione peroxidase (GPX2) on 14q24.1 by in situ hybridization. |journal=Genomics |volume=32 |issue= 2 |pages= 272–6 |year= 1997 |pmid= 8833155 |doi= 10.1006/geno.1996.0115
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Opalenik SR, Ding Q, Mallery SR, Thompson JA |title=Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor. |journal=Arch. Biochem. Biophys. |volume=351 |issue= 1 |pages= 17–26 |year= 1998 |pmid= 9501919 |doi= 10.1006/abbi.1997.0566
*cite journal | author=Choi J, Liu RM, Kundu RK, "et al." |title=Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3693–8 |year= 2000 |pmid= 10652368 |doi=
*cite journal | author=Kelner MJ, Bagnell RD, Montoya MA, Lanham KA |title=Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents. |journal=Gene |volume=248 |issue= 1-2 |pages= 109–16 |year= 2000 |pmid= 10806356 |doi=
*cite journal | author=Richard MJ, Guiraud P, Didier C, "et al." |title=Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation. |journal=Arch. Biochem. Biophys. |volume=386 |issue= 2 |pages= 213–20 |year= 2001 |pmid= 11368344 |doi= 10.1006/abbi.2000.2197
*cite journal | author=Komatsu H, Okayasu I, Mitomi H, "et al." |title=Immunohistochemical detection of human gastrointestinal glutathione peroxidase in normal tissues and cultured cells with novel mouse monoclonal antibodies. |journal=J. Histochem. Cytochem. |volume=49 |issue= 6 |pages= 759–66 |year= 2001 |pmid= 11373322 |doi=
*cite journal | author=Florian S, Wingler K, Schmehl K, "et al." |title=Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue. |journal=Free Radic. Res. |volume=35 |issue= 6 |pages= 655–63 |year= 2002 |pmid= 11811519 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Müller C, Wingler K, Brigelius-Flohé R |title=3'UTRs of glutathione peroxidases differentially affect selenium-dependent mRNA stability and selenocysteine incorporation efficiency. |journal=Biol. Chem. |volume=384 |issue= 1 |pages= 11–8 |year= 2003 |pmid= 12674495 |doi=
*cite journal | author=Esworthy RS, Binder SW, Doroshow JH, Chu FF |title=Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression. |journal=Biol. Chem. |volume=384 |issue= 4 |pages= 597–607 |year= 2003 |pmid= 12751789 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Price TO, Ercal N, Nakaoke R, Banks WA |title=HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. |journal=Brain Res. |volume=1045 |issue= 1-2 |pages= 57–63 |year= 2005 |pmid= 15910762 |doi= 10.1016/j.brainres.2005.03.031
*cite journal | author=Banning A, Deubel S, Kluth D, "et al." |title=The GI-GPx gene is a target for Nrf2. |journal=Mol. Cell. Biol. |volume=25 |issue= 12 |pages= 4914–23 |year= 2005 |pmid= 15923610 |doi= 10.1128/MCB.25.12.4914-4923.2005
*cite journal | author=Yan W, Chen X |title=GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner. |journal=J. Biol. Chem. |volume=281 |issue= 12 |pages= 7856–62 |year= 2006 |pmid= 16446369 |doi= 10.1074/jbc.M512655200
*cite journal | author=Singh A, Rangasamy T, Thimmulappa RK, "et al." |title=Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. |journal=Am. J. Respir. Cell Mol. Biol. |volume=35 |issue= 6 |pages= 639–50 |year= 2007 |pmid= 16794261 |doi= 10.1165/rcmb.2005-0325OC

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