PRAME

PRAME

Preferentially expressed antigen in melanoma, also known as PRAME, is a human gene.cite web | title = Entrez Gene: PRAME preferentially expressed antigen in melanoma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23532| accessdate = ]

PBB_Summary
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summary_text = This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.cite web | title = Entrez Gene: PRAME preferentially expressed antigen in melanoma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23532| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kirkin AF, Dzhandzhugazyan K, Zeuthen J |title=The immunogenic properties of melanoma-associated antigens recognized by cytotoxic T lymphocytes. |journal=Exp. Clin. Immunogenet. |volume=15 |issue= 1 |pages= 19–32 |year= 1998 |pmid= 9619397 |doi=
*cite journal | author=Matsushita M, Yamazaki R, Ikeda H, Kawakami Y |title=Preferentially expressed antigen of melanoma (PRAME) in the development of diagnostic and therapeutic methods for hematological malignancies. |journal=Leuk. Lymphoma |volume=44 |issue= 3 |pages= 439–44 |year= 2003 |pmid= 12688312 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ikeda H, Lethé B, Lehmann F, "et al." |title=Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. |journal=Immunity |volume=6 |issue= 2 |pages= 199–208 |year= 1997 |pmid= 9047241 |doi=
*cite journal | author=Williams JM, Chen GC, Zhu L, Rest RF |title=Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. |journal=Mol. Microbiol. |volume=27 |issue= 1 |pages= 171–86 |year= 1998 |pmid= 9466265 |doi=
*cite journal | author=Neumann E, Engelsberg A, Decker J, "et al." |title=Heterogeneous expression of the tumor-associated antigens RAGE-1, PRAME, and glycoprotein 75 in human renal cell carcinoma: candidates for T-cell-based immunotherapies? |journal=Cancer Res. |volume=58 |issue= 18 |pages= 4090–5 |year= 1998 |pmid= 9751617 |doi=
*cite journal | author=van Baren N, Chambost H, Ferrant A, "et al." |title=PRAME, a gene encoding an antigen recognized on a human melanoma by cytolytic T cells, is expressed in acute leukaemia cells. |journal=Br. J. Haematol. |volume=102 |issue= 5 |pages= 1376–9 |year= 1998 |pmid= 9753074 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Watari K, Tojo A, Nagamura-Inoue T, "et al." |title=Identification of a melanoma antigen, PRAME, as a BCR/ABL-inducible gene. |journal=FEBS Lett. |volume=466 |issue= 2-3 |pages= 367–71 |year= 2000 |pmid= 10682862 |doi=
*cite journal | author=Pellat-Deceunynck C, Mellerin MP, Labarrière N, "et al." |title=The cancer germ-line genes MAGE-1, MAGE-3 and PRAME are commonly expressed by human myeloma cells. |journal=Eur. J. Immunol. |volume=30 |issue= 3 |pages= 803–9 |year= 2000 |pmid= 10741395 |doi= 10.1002/1521-4141(200003)30:3<803::AID-IMMU803>3.0.CO;2-P |doilabel=10.1002/1521-4141(200003)30:3803::AID-IMMU8033.0.CO;2-P
*cite journal | author=Matsushita M, Ikeda H, Kizaki M, "et al." |title=Quantitative monitoring of the PRAME gene for the detection of minimal residual disease in leukaemia. |journal=Br. J. Haematol. |volume=112 |issue= 4 |pages= 916–26 |year= 2001 |pmid= 11298586 |doi=
*cite journal | author=Steinbach D, Hermann J, Viehmann S, "et al." |title=Clinical implications of PRAME gene expression in childhood acute myeloid leukemia. |journal=Cancer Genet. Cytogenet. |volume=133 |issue= 2 |pages= 118–23 |year= 2002 |pmid= 11943337 |doi=
*cite journal | author=Steinbach D, Viehmann S, Zintl F, Gruhn B |title=PRAME gene expression in childhood acute lymphoblastic leukemia. |journal=Cancer Genet. Cytogenet. |volume=138 |issue= 1 |pages= 89–91 |year= 2002 |pmid= 12419593 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=
*cite journal | author=Oberthuer A, Hero B, Spitz R, "et al." |title=The tumor-associated antigen PRAME is universally expressed in high-stage neuroblastoma and associated with poor outcome. |journal=Clin. Cancer Res. |volume=10 |issue= 13 |pages= 4307–13 |year= 2005 |pmid= 15240516 |doi= 10.1158/1078-0432.CCR-03-0813
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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