MAPK8IP3

Mitogen-activated protein kinase 8 interacting protein 3, also known as MAPK8IP3, is a human gene.cite web | title = Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23162| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.cite web | title = Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23162| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kikuno R, Nagase T, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=
*cite journal | author=Ito M, Yoshioka K, Akechi M, "et al." |title=JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway. |journal=Mol. Cell. Biol. |volume=19 |issue= 11 |pages= 7539–48 |year= 1999 |pmid= 10523642 |doi=
*cite journal | author=Kelkar N, Gupta S, Dickens M, Davis RJ |title=Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1030–43 |year= 2000 |pmid= 10629060 |doi=
*cite journal | author=Kuboki Y, Ito M, Takamatsu N, "et al." |title=A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 39815–8 |year= 2001 |pmid= 11044439 |doi= 10.1074/jbc.C000403200
*cite journal | author=Bowman AB, Kamal A, Ritchings BW, "et al." |title=Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. |journal=Cell |volume=103 |issue= 4 |pages= 583–94 |year= 2001 |pmid= 11106729 |doi=
*cite journal | author=Daniels RJ, Peden JF, Lloyd C, "et al." |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=
*cite journal | author=Hattori A, Okumura K, Nagase T, "et al." |title=Characterization of long cDNA clones from human adult spleen. |journal=DNA Res. |volume=7 |issue= 6 |pages= 357–66 |year= 2001 |pmid= 11214971 |doi=
*cite journal | author=Akechi M, Ito M, Uemura K, "et al." |title=Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system. |journal=Neurosci. Res. |volume=39 |issue= 4 |pages= 391–400 |year= 2001 |pmid= 11274738 |doi=
*cite journal | author=Byrd DT, Kawasaki M, Walcoff M, "et al." |title=UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans. |journal=Neuron |volume=32 |issue= 5 |pages= 787–800 |year= 2002 |pmid= 11738026 |doi=
*cite journal | author=Matsuura H, Nishitoh H, Takeda K, "et al." |title=Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40703–9 |year= 2002 |pmid= 12189133 |doi= 10.1074/jbc.M202004200
*cite journal | author=Takino T, Yoshioka K, Miyamori H, "et al." |title=A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated. |journal=Oncogene |volume=21 |issue= 42 |pages= 6488–97 |year= 2002 |pmid= 12226752 |doi= 10.1038/sj.onc.1205840
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Morita N, Iizuka K, Murakami T, Kawaguchi H |title=N-terminal kinase, and c-Src are activated in human aortic smooth muscle cells by pressure stress. |journal=Mol. Cell. Biochem. |volume=262 |issue= 1-2 |pages= 71–8 |year= 2005 |pmid= 15532711 |doi=
*cite journal | author=Martin J, Han C, Gordon LA, "et al." |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988–94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187
*cite journal | author=Song JJ, Lee YJ |title=Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. |journal=J. Biol. Chem. |volume=280 |issue= 29 |pages= 26845–55 |year= 2005 |pmid= 15911620 |doi= 10.1074/jbc.M502318200
*cite journal | author=Takino T, Nakada M, Miyamori H, "et al." |title=JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37772–81 |year= 2006 |pmid= 16141199 |doi= 10.1074/jbc.M505241200
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2

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