CLK1

CDC-like kinase 1, also known as CLK1, is a human gene.cite web | title = Entrez Gene: CLK1 CDC-like kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1195| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.cite web | title = Entrez Gene: CLK1 CDC-like kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1195| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Johnson KW, Smith KA |title=Molecular cloning of a novel human cdc2/CDC28-like protein kinase. |journal=J. Biol. Chem. |volume=266 |issue= 6 |pages= 3402–7 |year= 1991 |pmid= 1704889 |doi=
*cite journal | author=Ben-David Y, Letwin K, Tannock L, "et al." |title=A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. |journal=EMBO J. |volume=10 |issue= 2 |pages= 317–25 |year= 1991 |pmid= 1825055 |doi=
*cite journal | author=Hanes J, von der Kammer H, Klaudiny J, Scheit KH |title=Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. |journal=J. Mol. Biol. |volume=244 |issue= 5 |pages= 665–72 |year= 1995 |pmid= 7990150 |doi= 10.1006/jmbi.1994.1763
*cite journal | author=Colwill K, Pawson T, Andrews B, "et al." |title=The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. |journal=EMBO J. |volume=15 |issue= 2 |pages= 265–75 |year= 1996 |pmid= 8617202 |doi=
*cite journal | author=Colwill K, Feng LL, Yeakley JM, "et al." |title=SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24569–75 |year= 1996 |pmid= 8798720 |doi=
*cite journal | author=Nestel FP, Colwill K, Harper S, "et al." |title=RS cyclophilins: identification of an NK-TR1-related cyclophilin. |journal=Gene |volume=180 |issue= 1-2 |pages= 151–5 |year= 1997 |pmid= 8973360 |doi=
*cite journal | author=Talmadge CB, Finkernagel S, Sumegi J, "et al." |title=Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. |journal=Hum. Genet. |volume=103 |issue= 4 |pages= 523–4 |year= 1998 |pmid= 9856501 |doi=
*cite journal | author=Moeslein FM, Myers MP, Landreth GE |title=The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. |journal=J. Biol. Chem. |volume=274 |issue= 38 |pages= 26697–704 |year= 1999 |pmid= 10480872 |doi=
*cite journal | author=Menegay HJ, Myers MP, Moeslein FM, Landreth GE |title=Biochemical characterization and localization of the dual specificity kinase CLK1. |journal=J. Cell. Sci. |volume=113 ( Pt 18) |issue= |pages= 3241–53 |year= 2000 |pmid= 10954422 |doi=
*cite journal | author=Kojima T, Zama T, Wada K, "et al." |title=Cloning of human PRP4 reveals interaction with Clk1. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32247–56 |year= 2001 |pmid= 11418604 |doi= 10.1074/jbc.M103790200
*cite journal | author=Hartmann AM, Rujescu D, Giannakouros T, "et al." |title=Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors. |journal=Mol. Cell. Neurosci. |volume=18 |issue= 1 |pages= 80–90 |year= 2001 |pmid= 11461155 |doi= 10.1006/mcne.2001.1000
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lai MC, Lin RI, Tarn WY |title=Differential effects of hyperphosphorylation on splicing factor SRp55. |journal=Biochem. J. |volume=371 |issue= Pt 3 |pages= 937–45 |year= 2003 |pmid= 12549978 |doi= 10.1042/BJ20021827
*cite journal | author=Umehara H, Nishii Y, Morishima M, "et al." |title=Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 324–9 |year= 2003 |pmid= 12565863 |doi=
*cite journal | author=Kantham L, Kerr-Bayles L, Godde N, "et al." |title=Beacon interacts with cdc2/cdc28-like kinases. |journal=Biochem. Biophys. Res. Commun. |volume=304 |issue= 1 |pages= 125–9 |year= 2003 |pmid= 12705895 |doi=
*cite journal | author=Prasad J, Manley JL |title=Regulation and substrate specificity of the SR protein kinase Clk/Sty. |journal=Mol. Cell. Biol. |volume=23 |issue= 12 |pages= 4139–49 |year= 2003 |pmid= 12773558 |doi=
*cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8
*cite journal | author=Muraki M, Ohkawara B, Hosoya T, "et al." |title=Manipulation of alternative splicing by a newly developed inhibitor of Clks. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24246–54 |year= 2004 |pmid= 15010457 |doi= 10.1074/jbc.M314298200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Velazquez-Dones A, Hagopian JC, Ma CT, "et al." |title=Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41761–8 |year= 2006 |pmid= 16223727 |doi= 10.1074/jbc.M504156200

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