NIN (gene)
Ninein (GSK3B interacting protein)
Identifiers
Symbols NIN; KIAA1565
External IDs OMIM608684 MGI105108 HomoloGene40632 GeneCards: NIN Gene
Orthologs
Species Human Mouse
Entrez 51199 18080
Ensembl ENSG00000100503 ENSMUSG00000021068
UniProt Q8N4C6 Q3UR16
RefSeq (mRNA) NM_016350.4 NM_001081453
RefSeq (protein) NP_057434.4 NP_001074922
Location (UCSC) Chr 14:
51.19 – 51.3 Mb
Chr 12:
71.11 – 71.21 Mb
PubMed search [1] [2]

Ninein is a protein that in humans is encoded by the NIN gene.[1][2][3] Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.[3]

References

  1. ^ Hong YR, Chen CH, Chang JH, Wang S, Sy WD, Chou CK, Howng SL (Oct 2000). "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta 1492 (2–3): 513–6. doi:10.1016/S0167-4781(00)00127-5. PMID 11004522. 
  2. ^ Hong YR, Chen CH, Chuo MH, Liou SY, Howng SL (Feb 2001). "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun. 279 (3): 989–95. doi:10.1006/bbrc.2000.4050. PMID 11162463. 
  3. ^ a b "Entrez Gene: NIN ninein (GSK3B interacting protein)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51199. 

Further reading



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