CCT5 (gene)

Chaperonin containing TCP1, subunit 5 (epsilon), also known as CCT5, is a human gene.cite web | title = Entrez Gene: CCT5 chaperonin containing TCP1, subunit 5 (epsilon)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22948| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.cite web | title = Entrez Gene: CCT5 chaperonin containing TCP1, subunit 5 (epsilon)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22948| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Roobol A, Holmes FE, Hayes NV, "et al." |title=Cytoplasmic chaperonin complexes enter neurites developing in vitro and differ in subunit composition within single cells. |journal=J. Cell. Sci. |volume=108 ( Pt 4) |issue= |pages= 1477–88 |year= 1995 |pmid= 7615668 |doi=
*cite journal | author=Nagase T, Miyajima N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 1 |pages= 37–43 |year= 1995 |pmid= 7788527 |doi=
*cite journal | author=Kubota H, Hynes G, Carne A, "et al." |title=Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. |journal=Curr. Biol. |volume=4 |issue= 2 |pages= 89–99 |year= 1994 |pmid= 7953530 |doi=
*cite journal | author=Liou AK, Willison KR |title=Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes. |journal=EMBO J. |volume=16 |issue= 14 |pages= 4311–6 |year= 1997 |pmid= 9250675 |doi=
*cite journal | author=Roperch JP, Lethrone F, Prieur S, "et al." |title=SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 14 |pages= 8070–3 |year= 1999 |pmid= 10393949 |doi=
*cite journal | author=Yanaka N, Kobayashi K, Wakimoto K, "et al." |title=Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 14791–4 |year= 2000 |pmid= 10747865 |doi= 10.1074/jbc.C901047199
*cite journal | author=Yoo BC, Kim SH, Cairns N, "et al." |title=Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 1 |pages= 249–58 |year= 2001 |pmid= 11162507 |doi= 10.1006/bbrc.2000.4109
*cite journal | author=Yoo BC, Vlkolinsky R, Engidawork E, "et al." |title=Differential expression of molecular chaperones in brain of patients with Down syndrome. |journal=Electrophoresis |volume=22 |issue= 6 |pages= 1233–41 |year= 2001 |pmid= 11358150 |doi= 10.1002/1522-2683()22:6<1233::AID-ELPS1233>3.0.CO;2-M |doilabel=10.1002/1522-2683()22:61233::AID-ELPS12333.0.CO;2-M
*cite journal | author=Yokota S, Yanagi H, Yura T, Kubota H |title=Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. |journal=Eur. J. Biochem. |volume=268 |issue= 17 |pages= 4664–73 |year= 2001 |pmid= 11532003 |doi=
*cite journal | author=McCormack EA, Llorca O, Carrascosa JL, "et al." |title=Point mutations in a hinge linking the small and large domains of beta-actin result in trapped folding intermediates bound to cytosolic chaperonin CCT. |journal=J. Struct. Biol. |volume=135 |issue= 2 |pages= 198–204 |year= 2002 |pmid= 11580269 |doi= 10.1006/jsbi.2001.4385
*cite journal | author=Llorca O, Martín-Benito J, Gómez-Puertas P, "et al." |title=Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin. |journal=J. Struct. Biol. |volume=135 |issue= 2 |pages= 205–18 |year= 2002 |pmid= 11580270 |doi= 10.1006/jsbi.2001.4359
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Guenther MG, Yu J, Kao GD, "et al." |title=Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. |journal=Genes Dev. |volume=16 |issue= 24 |pages= 3130–5 |year= 2003 |pmid= 12502735 |doi= 10.1101/gad.1037502
*cite journal | author=Ludwig A, Dietel M, Lage H |title=Identification of differentially expressed genes in classical and atypical multidrug-resistant gastric carcinoma cells. |journal=Anticancer Res. |volume=22 |issue= 6A |pages= 3213–21 |year= 2003 |pmid= 12530067 |doi=
*cite journal | author=Imai Y, Soda M, Murakami T, "et al." |title=A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51901–10 |year= 2004 |pmid= 14532270 |doi= 10.1074/jbc.M309655200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lukov GL, Hu T, McLaughlin JN, "et al." |title=Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly. |journal=EMBO J. |volume=24 |issue= 11 |pages= 1965–75 |year= 2005 |pmid= 15889144 |doi= 10.1038/sj.emboj.7600673
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029

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