ACTR1A

ARP1 actin-related protein 1 homolog A, centractin alpha (yeast), also known as ACTR1A, is a human gene.cite web | title = Entrez Gene: ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10121| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.cite web | title = Entrez Gene: ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10121| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Clark SW, Meyer DI |title=Centractin is an actin homologue associated with the centrosome. |journal=Nature |volume=359 |issue= 6392 |pages= 246–50 |year= 1992 |pmid= 1356230 |doi= 10.1038/359246a0
*cite journal | author=Lees-Miller JP, Helfman DM, Schroer TA |title=A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. |journal=Nature |volume=359 |issue= 6392 |pages= 244–6 |year= 1992 |pmid= 1528266 |doi= 10.1038/359244a0
*cite journal | author=Schafer DA, Gill SR, Cooper JA, "et al." |title=Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin. |journal=J. Cell Biol. |volume=126 |issue= 2 |pages= 403–12 |year= 1994 |pmid= 7518465 |doi=
*cite journal | author=Clark SW, Staub O, Clark IB, "et al." |title=Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. |journal=Mol. Biol. Cell |volume=5 |issue= 12 |pages= 1301–10 |year= 1995 |pmid= 7696711 |doi=
*cite journal | author=Waterman-Storer CM, Karki S, Holzbaur EL |title=The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1634–8 |year= 1995 |pmid= 7878030 |doi=
*cite journal | author=Holleran EA, Tokito MK, Karki S, Holzbaur EL |title=Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles. |journal=J. Cell Biol. |volume=135 |issue= 6 Pt 2 |pages= 1815–29 |year= 1997 |pmid= 8991093 |doi=
*cite journal | author=Faulkner NE, Vig B, Echeverri CJ, "et al." |title=Localization of motor-related proteins and associated complexes to active, but not inactive, centromeres. |journal=Hum. Mol. Genet. |volume=7 |issue= 4 |pages= 671–7 |year= 1998 |pmid= 9499420 |doi=
*cite journal | author=Bingham JB, Schroer TA |title=Self-regulated polymerization of the actin-related protein Arp1. |journal=Curr. Biol. |volume=9 |issue= 4 |pages= 223–6 |year= 1999 |pmid= 10074429 |doi=
*cite journal | author=Heimann K, Percival JM, Weinberger R, "et al." |title=Specific isoforms of actin-binding proteins on distinct populations of Golgi-derived vesicles. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 10743–50 |year= 1999 |pmid= 10196146 |doi=
*cite journal | author=Clark IB, Meyer DI |title=Overexpression of normal and mutant Arp1alpha (centractin) differentially affects microtubule organization during mitosis and interphase. |journal=J. Cell. Sci. |volume=112 ( Pt 20) |issue= |pages= 3507–18 |year= 2000 |pmid= 10504299 |doi=
*cite journal | author=Saffery R, Irvine DV, Griffiths B, "et al." |title=Human centromeres and neocentromeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins. |journal=Hum. Mol. Genet. |volume=9 |issue= 2 |pages= 175–85 |year= 2000 |pmid= 10607828 |doi=
*cite journal | author=Fouquet J, Kann M, Souès S, Melki R |title=ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis. |journal=J. Cell. Sci. |volume=113 ( Pt 5) |issue= |pages= 877–86 |year= 2000 |pmid= 10671377 |doi=
*cite journal | author=Karki S, Tokito MK, Holzbaur EL |title=A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. |journal=J. Biol. Chem. |volume=275 |issue= 7 |pages= 4834–9 |year= 2000 |pmid= 10671518 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Holleran EA, Ligon LA, Tokito M, "et al." |title=beta III spectrin binds to the Arp1 subunit of dynactin. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36598–605 |year= 2001 |pmid= 11461920 |doi= 10.1074/jbc.M104838200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Carew JA, Jackson AA, Bauer KA |title=ARP1 interacts with the 5' flanking region of the coagulation factor VII gene. |journal=J. Thromb. Haemost. |volume=1 |issue= 6 |pages= 1220–7 |year= 2004 |pmid= 12871323 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes