RAD21

RAD21

RAD21 homolog (S. pombe), also known as RAD21, is a human gene.cite web | title = Entrez Gene: RAD21 RAD21 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5885| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.cite web | title = Entrez Gene: RAD21 RAD21 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5885| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nomura N, Nagase T, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=
*cite journal | author=McKay MJ, Troelstra C, van der Spek P, "et al." |title=Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse. |journal=Genomics |volume=36 |issue= 2 |pages= 305–15 |year= 1997 |pmid= 8812457 |doi=
*cite journal | author=Parisi S, McKay MJ, Molnar M, "et al." |title=Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. |journal=Mol. Cell. Biol. |volume=19 |issue= 5 |pages= 3515–28 |year= 1999 |pmid= 10207075 |doi=
*cite journal | author=Sadano H, Sugimoto H, Sakai F, "et al." |title=NXP-1, a human protein related to Rad21/Scc1/Mcd1, is a component of the nuclear matrix. |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue= 1 |pages= 418–22 |year= 2000 |pmid= 10623634 |doi= 10.1006/bbrc.1999.1969
*cite journal | author=Losada A, Yokochi T, Kobayashi R, Hirano T |title=Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes. |journal=J. Cell Biol. |volume=150 |issue= 3 |pages= 405–16 |year= 2000 |pmid= 10931856 |doi=
*cite journal | author=Hoque MT, Ishikawa F |title=Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5059–67 |year= 2001 |pmid= 11073952 |doi= 10.1074/jbc.M007809200
*cite journal | author=Sumara I, Vorlaufer E, Gieffers C, "et al." |title=Characterization of vertebrate cohesin complexes and their regulation in prophase. |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 749–62 |year= 2000 |pmid= 11076961 |doi=
*cite journal | author=Sook Kim M, Hyen Baek J, Bae MK, Kim KW |title=Human rad21 gene, hHR21(SP), is downregulated by hypoxia in human tumor cells. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 5 |pages= 1106–12 |year= 2001 |pmid= 11243849 |doi= 10.1006/bbrc.2001.4488
*cite journal | author=Severin DM, Leong T, Cassidy B, "et al." |title=Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients. |journal=Int. J. Radiat. Oncol. Biol. Phys. |volume=50 |issue= 5 |pages= 1323–31 |year= 2001 |pmid= 11483345 |doi=
*cite journal | author=Hauf S, Waizenegger IC, Peters JM |title=Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. |journal=Science |volume=293 |issue= 5533 |pages= 1320–3 |year= 2001 |pmid= 11509732 |doi= 10.1126/science.1061376
*cite journal | author=Gregson HC, Schmiesing JA, Kim JS, "et al." |title=A potential role for human cohesin in mitotic spindle aster assembly. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47575–82 |year= 2002 |pmid= 11590136 |doi= 10.1074/jbc.M103364200
*cite journal | author=Deng Y, Li S, Li X, Magali T |title=Expression of hHR21sp gene by peripheral blood and hematopoietic cells of normal subjects and Fanconi anemia patients. |journal=Chin. Med. J. |volume=114 |issue= 12 |pages= 1295–9 |year= 2002 |pmid= 11793857 |doi=
*cite journal | author=Chen F, Kamradt M, Mulcahy M, "et al." |title=Caspase proteolysis of the cohesin component RAD21 promotes apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16775–81 |year= 2002 |pmid= 11875078 |doi= 10.1074/jbc.M201322200
*cite journal | author=Prieto I, Pezzi N, Buesa JM, "et al." |title=STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis. |journal=EMBO Rep. |volume=3 |issue= 6 |pages= 543–50 |year= 2003 |pmid= 12034751 |doi= 10.1093/embo-reports/kvf108
*cite journal | author=Hakimi MA, Bochar DA, Schmiesing JA, "et al." |title=A chromatin remodelling complex that loads cohesin onto human chromosomes. |journal=Nature |volume=418 |issue= 6901 |pages= 994–8 |year= 2002 |pmid= 12198550 |doi= 10.1038/nature01024
*cite journal | author=Hoque MT, Ishikawa F |title=Cohesin defects lead to premature sister chromatid separation, kinetochore dysfunction, and spindle-assembly checkpoint activation. |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42306–14 |year= 2003 |pmid= 12200439 |doi= 10.1074/jbc.M206836200
*cite journal | author=Pati D, Zhang N, Plon SE |title=Linking sister chromatid cohesion and apoptosis: role of Rad21. |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8267–77 |year= 2003 |pmid= 12417729 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chestukhin A, Pfeffer C, Milligan S, "et al." |title=Processing, localization, and requirement of human separase for normal anaphase progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4574–9 |year= 2003 |pmid= 12672959 |doi= 10.1073/pnas.0730733100
*cite journal | author=Porkka KP, Tammela TL, Vessella RL, Visakorpi T |title=RAD21 and KIAA0196 at 8q24 are amplified and overexpressed in prostate cancer. |journal=Genes Chromosomes Cancer |volume=39 |issue= 1 |pages= 1–10 |year= 2004 |pmid= 14603436 |doi= 10.1002/gcc.10289

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