- CTSE
Cathepsin E, also known as CTSE, is a human
gene .cite web | title = Entrez Gene: CTSE cathepsin E| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1510| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.cite web | title = Entrez Gene: CTSE cathepsin E| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1510| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Tsukuba T, Yamamoto K |title= [Atopic dermatitis and cathepsin E] |journal=Nippon Yakurigaku Zasshi |volume=122 |issue= 1 |pages= 15–20 |year= 2003 |pmid= 12843568 |doi=
*cite journal | author=Flynn TJ, Deshmukh DS, Pieringer RA |title=Effects of altered thyroid function on galactosyl diacylglycerol metabolism in myelinating rat brain. |journal=J. Biol. Chem. |volume=252 |issue= 16 |pages= 5864–70 |year= 1977 |pmid= 195962 |doi=
*cite journal | author=Azuma T, Liu WG, Vander Laan DJ, "et al." |title=Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32. |journal=J. Biol. Chem. |volume=267 |issue= 3 |pages= 1609–14 |year= 1992 |pmid= 1370478 |doi=
*cite journal | author=Saku T, Sakai H, Shibata Y, "et al." |title=An immunocytochemical study on distinct intracellular localization of cathepsin E and cathepsin D in human gastric cells and various rat cells. |journal=J. Biochem. |volume=110 |issue= 6 |pages= 956–64 |year= 1992 |pmid= 1794985 |doi=
*cite journal | author=Athauda SB, Takahashi T, Inoue H, "et al." |title=Proteolytic activity and cleavage specificity of cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin. |journal=FEBS Lett. |volume=292 |issue= 1-2 |pages= 53–6 |year= 1992 |pmid= 1959628 |doi=
*cite journal | author=Lees WE, Kalinka S, Meech J, "et al." |title=Generation of human endothelin by cathepsin E. |journal=FEBS Lett. |volume=273 |issue= 1-2 |pages= 99–102 |year= 1990 |pmid= 2226872 |doi=
*cite journal | author=Athauda SB, Matsuzaki O, Kageyama T, Takahashi K |title=Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E. |journal=Biochem. Biophys. Res. Commun. |volume=168 |issue= 2 |pages= 878–85 |year= 1990 |pmid= 2334440 |doi=
*cite journal | author=Couvreur JM, Azuma T, Miller DA, "et al." |title=Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. |journal=Cytogenet. Cell Genet. |volume=53 |issue= 2-3 |pages= 137–9 |year= 1990 |pmid= 2369841 |doi=
*cite journal | author=Azuma T, Pals G, Mohandas TK, "et al." |title=Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases. |journal=J. Biol. Chem. |volume=264 |issue= 28 |pages= 16748–53 |year= 1989 |pmid= 2674141 |doi=
*cite journal | author=Fowler SD, Kay J, Dunn BM, Tatnell PJ |title=Monomeric human cathepsin E. |journal=FEBS Lett. |volume=366 |issue= 1 |pages= 72–4 |year= 1995 |pmid= 7789521 |doi=
*cite journal | author=Finley EM, Kornfeld S |title=Subcellular localization and targeting of cathepsin E. |journal=J. Biol. Chem. |volume=269 |issue= 49 |pages= 31259–66 |year= 1995 |pmid= 7983070 |doi=
*cite journal | author=Takeda-Ezaki M, Yamamoto K |title=Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes. |journal=Arch. Biochem. Biophys. |volume=304 |issue= 2 |pages= 352–8 |year= 1993 |pmid= 8346912 |doi=
*cite journal | author=Schulz TF, Reeves JD, Hoad JG, "et al." |title=Effect of mutations in the V3 loop of HIV-1 gp120 on infectivity and susceptibility to proteolytic cleavage. |journal=AIDS Res. Hum. Retroviruses |volume=9 |issue= 2 |pages= 159–66 |year= 1993 |pmid= 8457383 |doi=
*cite journal | author=Finzi G, Cornaggia M, Capella C, "et al." |title=Cathepsin E in follicle associated epithelium of intestine and tonsils: localization to M cells and possible role in antigen processing. |journal=Histochemistry |volume=99 |issue= 3 |pages= 201–11 |year= 1993 |pmid= 8491674 |doi=
*cite journal | author=Azuma T, Hirai M, Ito S, "et al." |title=Expression of cathepsin E in pancreas: a possible tumor marker for pancreas, a preliminary report. |journal=Int. J. Cancer |volume=67 |issue= 4 |pages= 492–7 |year= 1996 |pmid= 8759606 |doi= 10.1002/(SICI)1097-0215(19960807)67:4<492::AID-IJC5>3.0.CO;2-N |doilabel=10.1002/(SICI)1097-0215(19960807)67:4492::AID-IJC53.0.CO;2-N
*cite journal | author=Sealy L, Mota F, Rayment N, "et al." |title=Regulation of cathepsin E expression during human B cell differentiation in vitro. |journal=Eur. J. Immunol. |volume=26 |issue= 8 |pages= 1838–43 |year= 1996 |pmid= 8765029 |doi=
*cite journal | author=Bernstein HG, Reichenbach A, Wiederanders B |title=Cathepsin E immunoreactivity in human ocular tissues: influence of aging and pathological states. |journal=Neurosci. Lett. |volume=240 |issue= 3 |pages= 135–8 |year= 1998 |pmid= 9502222 |doi=
*cite journal | author=Cook M, Caswell RC, Richards RJ, "et al." |title=Regulation of human and mouse procathepsin E gene expression. |journal=Eur. J. Biochem. |volume=268 |issue= 9 |pages= 2658–68 |year= 2001 |pmid= 11322887 |doi=
*cite journal | author=Suzuki Y, Tsunoda T, Sese J, "et al." |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899PBB_Controls
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