Nucleolar phosphoprotein p130

Nucleolar and coiled-body phosphoprotein 1
Identifiers
Symbols	NOLC1; KIAA0035; NOPP130; NOPP140; NS5ATP13; P130
External IDs	OMIM: 602394 MGI: 1918019 HomoloGene: 68818 GeneCards: NOLC1 Gene
Gene Ontology Molecular function • nucleotide binding • sequence-specific DNA binding transcription factor activity • protein binding • ATP binding • GTP binding • nuclear localization sequence binding • box C/D snoRNA binding • box H/ACA snoRNA binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • Cajal body Biological process • rRNA processing • response to osmotic stress • nucleolus organization • cell cycle • mitosis • positive regulation of cell proliferation • box H/ACA snoRNA metabolic process • regulation of protein import into nucleus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9221	70769
Ensembl	ENSG00000166197	ENSMUSG00000015176
UniProt	Q14978	n/a
RefSeq (mRNA)	NM_004741	NM_001039351
RefSeq (protein)	NP_004732	NP_001034440
Location (UCSC)	Chr 10: 103.91 – 103.92 Mb	Chr 19: 46.15 – 46.16 Mb
PubMed search	[1]	[2]

Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene.^[1][2][3]

Interactions

Nucleolar phosphoprotein p130 has been shown to interact with Coilin^[4] and CEBPB.^[5]

References

1. ^ Pai CY, Chen HK, Sheu HL, Yeh NH (Oct 1995). "Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis". J Cell Sci. 108 ( Pt 5): 1911–20. PMID 7657714. 
2. ^ Chen HK, Pai CY, Huang JY, Yeh NH (Jan 2000). "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization". Mol Cell Biol 19 (12): 8536–46. PMC 84972. PMID 10567578. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84972. 
3. ^ "Entrez Gene: NOLC1 nucleolar and coiled-body phosphoprotein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9221. 
4. ^ Isaac, C; Yang Y, Meier U T (Jul. 1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies". J. Cell Biol. (UNITED STATES) 142 (2): 319–29. doi:10.1083/jcb.142.2.319. ISSN 0021-9525. PMC 2133063. PMID 9679133. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2133063. 
5. ^ Miau, L H; Chang C J, Shen B J, Tsai W H, Lee S C (Apr. 1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation". J. Biol. Chem. (UNITED STATES) 273 (17): 10784–91. doi:10.1074/jbc.273.17.10784. ISSN 0021-9258. PMID 9553145. 

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026. 
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Pai CY, Yeh NH (1996). "Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130.". Biochem. Biophys. Res. Commun. 221 (3): 581–7. doi:10.1006/bbrc.1996.0639. PMID 8630004. 
• Miau LH, Chang CJ, Tsai WH, Lee SC (1997). "Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor.". Mol. Cell. Biol. 17 (1): 230–9. PMC 231747. PMID 8972203. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231747. 
• Li D, Meier UT, Dobrowolska G, Krebs EG (1997). "Specific interaction between casein kinase 2 and the nucleolar protein Nopp140.". J. Biol. Chem. 272 (6): 3773–9. doi:10.1074/jbc.272.6.3773. PMID 9013635. 
• Chen HK, Yeh NH (1997). "The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+.". Biochem. Biophys. Res. Commun. 230 (2): 370–5. doi:10.1006/bbrc.1996.5966. PMID 9016786. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Miau LH, Chang CJ, Shen BJ, et al. (1998). "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation.". J. Biol. Chem. 273 (17): 10784–91. doi:10.1074/jbc.273.17.10784. PMID 9553145. 
• Isaac C, Yang Y, Meier UT (1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies.". J. Cell Biol. 142 (2): 319–29. doi:10.1083/jcb.142.2.319. PMC 2133063. PMID 9679133. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2133063. 
• Blanchette P, Gilchrist CA, Baker RT, Gray DA (2001). "Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130.". Oncogene 20 (39): 5533–7. doi:10.1038/sj.onc.1204823. PMID 11571651. 
• Chiu CM, Tsay YG, Chang CJ, Lee SC (2002). "Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene.". J. Biol. Chem. 277 (42): 39102–11. doi:10.1074/jbc.M205915200. PMID 12167624. 
• Wang C, Query CC, Meier UT (2003). "Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140.". Mol. Cell. Biol. 22 (24): 8457–66. doi:10.1128/MCB.22.24.8457-8466.2002. PMC 139890. PMID 12446766. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139890. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186. 
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.