PPP1R8

Protein phosphatase 1, regulatory (inhibitor) subunit 8, also known as PPP1R8, is a human gene.cite web | title = Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5511| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.cite web | title = Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5511| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Van Eynde A, Wera S, Beullens M, "et al." |title=Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing. |journal=J. Biol. Chem. |volume=270 |issue= 47 |pages= 28068–74 |year= 1996 |pmid= 7499293 |doi=
*cite journal | author=Wang M, Cohen SN |title=ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10591–5 |year= 1994 |pmid= 7524097 |doi=
*cite journal | author=Mishima K, Tsuchiya M, Nightingale MS, "et al." |title=ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain. |journal=J. Biol. Chem. |volume=268 |issue= 12 |pages= 8801–7 |year= 1993 |pmid= 8473324 |doi=
*cite journal | author=Claverie-Martin F, Wang M, Cohen SN |title=ARD-1 cDNA from human cells encodes a site-specific single-strand endoribonuclease that functionally resembles Escherichia coli RNase E. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13823–8 |year= 1997 |pmid= 9153239 |doi=
*cite journal | author=Vulsteke V, Beullens M, Waelkens E, "et al." |title=Properties and phosphorylation sites of baculovirus-expressed nuclear inhibitor of protein phosphatase-1 (NIPP-1). |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 32972–8 |year= 1998 |pmid= 9407077 |doi=
*cite journal | author=Van Eynde A, Pérez-Callejón E, Schoenmakers E, "et al." |title=Organization and alternate splice products of the gene encoding nuclear inhibitor of protein phosphatase-1 (NIPP-1). |journal=Eur. J. Biochem. |volume=261 |issue= 1 |pages= 291–300 |year= 1999 |pmid= 10103062 |doi=
*cite journal | author=Jin Q, Beullens M, Jagiello I, "et al." |title=Mapping of the RNA-binding and endoribonuclease domains of NIPP1, a nuclear targeting subunit of protein phosphatase 1. |journal=Biochem. J. |volume=342 ( Pt 1) |issue= |pages= 13–9 |year= 1999 |pmid= 10432294 |doi=
*cite journal | author=Chang AC, Sohlberg B, Trinkle-Mulcahy L, "et al." |title=Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene. |journal=Gene |volume=240 |issue= 1 |pages= 45–55 |year= 2000 |pmid= 10564811 |doi=
*cite journal | author=Boudrez A, Beullens M, Groenen P, "et al." |title=NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25411–7 |year= 2000 |pmid= 10827081 |doi= 10.1074/jbc.M001676200
*cite journal | author=Jagiello I, Van Eynde A, Vulsteke V, "et al." |title=Nuclear and subnuclear targeting sequences of the protein phosphatase-1 regulator NIPP1. |journal=J. Cell. Sci. |volume=113 Pt 21 |issue= |pages= 3761–8 |year= 2001 |pmid= 11034904 |doi=
*cite journal | author=Beullens M, Vulsteke V, Van Eynde A, "et al." |title=The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding. |journal=Biochem. J. |volume=352 Pt 3 |issue= |pages= 651–8 |year= 2001 |pmid= 11104670 |doi=
*cite journal | author=Trinkle-Mulcahy L, Sleeman JE, Lamond AI |title=Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4219–28 |year= 2002 |pmid= 11739654 |doi=
*cite journal | author=Beullens M, Bollen M |title=The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19855–60 |year= 2002 |pmid= 11909864 |doi= 10.1074/jbc.M200847200
*cite journal | author=Boudrez A, Beullens M, Waelkens E, "et al." |title=Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31834–41 |year= 2002 |pmid= 12105215 |doi= 10.1074/jbc.M204427200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ammosova T, Jerebtsova M, Beullens M, "et al." |title=Nuclear protein phosphatase-1 regulates HIV-1 transcription. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32189–94 |year= 2003 |pmid= 12788939 |doi= 10.1074/jbc.M300521200
*cite journal | author=Jin Q, van Eynde A, Beullens M, "et al." |title=The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30677–85 |year= 2003 |pmid= 12788942 |doi= 10.1074/jbc.M302273200
*cite journal | author=Vulsteke V, Beullens M, Boudrez A, "et al." |title=Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 8642–7 |year= 2004 |pmid= 14699119 |doi= 10.1074/jbc.M311466200
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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