CES1

Carboxylesterase 1 (monocyte/macrophage serine esterase 1), also known as CES1, is a human gene.cite web | title = Entrez Gene: CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1066| accessdate = ]

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summary_text = Carboxylesterase 1 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. Three transcript variants encoding three different isoforms have been found for this gene.cite web | title = Entrez Gene: CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1066| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Riddles PW, Richards LJ, Bowles MR, Pond SM |title=Cloning and analysis of a cDNA encoding a human liver carboxylesterase. |journal=Gene |volume=108 |issue= 2 |pages= 289–92 |year= 1992 |pmid= 1748313 |doi=
*cite journal | author=Munger JS, Shi GP, Mark EA, "et al." |title=A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases. |journal=J. Biol. Chem. |volume=266 |issue= 28 |pages= 18832–8 |year= 1991 |pmid= 1918003 |doi=
*cite journal | author=Long RM, Calabrese MR, Martin BM, Pohl LR |title=Cloning and sequencing of a human liver carboxylesterase isoenzyme. |journal=Life Sci. |volume=48 |issue= 11 |pages= PL43–9 |year= 1991 |pmid= 1997784 |doi=
*cite journal | author=Zschunke F, Salmassi A, Kreipe H, "et al." |title=cDNA cloning and characterization of human monocyte/macrophage serine esterase-1. |journal=Blood |volume=78 |issue= 2 |pages= 506–12 |year= 1991 |pmid= 2070086 |doi=
*cite journal | author=Ketterman AJ, Bowles MR, Pond SM |title=Purification and characterization of two human liver carboxylesterases. |journal=Int. J. Biochem. |volume=21 |issue= 12 |pages= 1303–12 |year= 1990 |pmid= 2612723 |doi=
*cite journal | author=Becker A, Böttcher A, Lackner KJ, "et al." |title=Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase. |journal=Arterioscler. Thromb. |volume=14 |issue= 8 |pages= 1346–55 |year= 1994 |pmid= 8049197 |doi=
*cite journal | author=Kroetz DL, McBride OW, Gonzalez FJ |title=Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms. |journal=Biochemistry |volume=32 |issue= 43 |pages= 11606–17 |year= 1993 |pmid= 8218228 |doi=
*cite journal | author=Shibata F, Takagi Y, Kitajima M, "et al." |title=Molecular cloning and characterization of a human carboxylesterase gene. |journal=Genomics |volume=17 |issue= 1 |pages= 76–82 |year= 1993 |pmid= 8406473 |doi= 10.1006/geno.1993.1285
*cite journal | author=Langmann T, Becker A, Aslanidis C, "et al." |title=Structural organization and characterization of the promoter region of a human carboxylesterase gene. |journal=Biochim. Biophys. Acta |volume=1350 |issue= 1 |pages= 65–74 |year= 1997 |pmid= 9003459 |doi=
*cite journal | author=Brzezinski MR, Spink BJ, Dean RA, "et al." |title=Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs. |journal=Drug Metab. Dispos. |volume=25 |issue= 9 |pages= 1089–96 |year= 1997 |pmid= 9311626 |doi=
*cite journal | author=Yan B, Matoney L, Yang D |title=Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. |journal=Placenta |volume=20 |issue= 7 |pages= 599–607 |year= 1999 |pmid= 10452915 |doi= 10.1053/plac.1999.0407
*cite journal | author=Mori M, Hosokawa M, Ogasawara Y, "et al." |title=cDNA cloning, characterization and stable expression of novel human brain carboxylesterase. |journal=FEBS Lett. |volume=458 |issue= 1 |pages= 17–22 |year= 1999 |pmid= 10518925 |doi=
*cite journal | author=Islam MR, Waheed A, Shah GN, "et al." |title=Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C terminus of beta-glucuronidase is involved in their interaction. |journal=Arch. Biochem. Biophys. |volume=372 |issue= 1 |pages= 53–61 |year= 1999 |pmid= 10562416 |doi= 10.1006/abbi.1999.1449
*cite journal | author=Ghosh S |title=Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA. |journal=Physiol. Genomics |volume=2 |issue= 1 |pages= 1–8 |year= 2001 |pmid= 11015575 |doi=
*cite journal | author=Ghosh S, Natarajan R |title=Cloning of the human cholesteryl ester hydrolase promoter: identification of functional peroxisomal proliferator-activated receptor responsive elements. |journal=Biochem. Biophys. Res. Commun. |volume=284 |issue= 4 |pages= 1065–70 |year= 2001 |pmid= 11409902 |doi= 10.1006/bbrc.2001.5078
*cite journal | author=Alam M, Ho S, Vance DE, Lehner R |title=Heterologous expression, purification, and characterization of human triacylglycerol hydrolase. |journal=Protein Expr. Purif. |volume=24 |issue= 1 |pages= 33–42 |year= 2002 |pmid= 11812220 |doi= 10.1006/prep.2001.1553
*cite journal | author=Satoh T, Taylor P, Bosron WF, "et al." |title=Current progress on esterases: from molecular structure to function. |journal=Drug Metab. Dispos. |volume=30 |issue= 5 |pages= 488–93 |year= 2002 |pmid= 11950776 |doi=
*cite journal | author=Alam M, Vance DE, Lehner R |title=Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site. |journal=Biochemistry |volume=41 |issue= 21 |pages= 6679–87 |year= 2002 |pmid= 12022871 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bencharit S, Morton CL, Xue Y, "et al." |title=Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. |journal=Nat. Struct. Biol. |volume=10 |issue= 5 |pages= 349–56 |year= 2003 |pmid= 12679808 |doi= 10.1038/nsb919

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