- MAP2K7
Mitogen-activated protein kinase kinase 7, also known as MAP2K7, is a human
gene .cite web | title = Entrez Gene: MAP2K7 mitogen-activated protein kinase kinase 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5609| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.cite web | title = Entrez Gene: MAP2K7 mitogen-activated protein kinase kinase 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5609| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Tournier C, Whitmarsh AJ, Cavanagh J, "et al." |title=Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 14 |pages= 7337–42 |year= 1997 |pmid= 9207092 |doi=
*cite journal | author=Lu X, Nemoto S, Lin A |title=Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 24751–4 |year= 1997 |pmid= 9312068 |doi=
*cite journal | author=Wu Z, Wu J, Jacinto E, Karin M |title=Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7407–16 |year= 1997 |pmid= 9372971 |doi=
*cite journal | author=Wang Y, Su B, Sah VP, "et al." |title=Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5423–6 |year= 1998 |pmid= 9488659 |doi=
*cite journal | author=Foltz IN, Gerl RE, Wieler JS, "et al." |title=Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 9344–51 |year= 1998 |pmid= 9535930 |doi=
*cite journal | author=Yang J, New L, Jiang Y, "et al." |title=Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase. |journal=Gene |volume=212 |issue= 1 |pages= 95–102 |year= 1998 |pmid= 9661668 |doi=
*cite journal | author=Merritt SE, Mata M, Nihalani D, "et al." |title=The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10195–202 |year= 1999 |pmid= 10187804 |doi=
*cite journal | author=Deacon K, Blank JL |title=MEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases. |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16604–10 |year= 1999 |pmid= 10347227 |doi=
*cite journal | author=Yasuda J, Whitmarsh AJ, Cavanagh J, "et al." |title=The JIP group of mitogen-activated protein kinase scaffold proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 7245–54 |year= 2000 |pmid= 10490659 |doi=
*cite journal | author=Kelkar N, Gupta S, Dickens M, Davis RJ |title=Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1030–43 |year= 2000 |pmid= 10629060 |doi=
*cite journal | author=Cheng J, Yang J, Xia Y, "et al." |title=Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2334–42 |year= 2000 |pmid= 10713157 |doi=
*cite journal | author=Negri S, Oberson A, Steinmann M, "et al." |title=cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein. |journal=Genomics |volume=64 |issue= 3 |pages= 324–30 |year= 2000 |pmid= 10756100 |doi= 10.1006/geno.2000.6129
*cite journal | author=Karandikar M, Xu S, Cobb MH |title=MEKK1 binds raf-1 and the ERK2 cascade components. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40120–7 |year= 2001 |pmid= 10969079 |doi= 10.1074/jbc.M005926200
*cite journal | author=Fleming Y, Armstrong CG, Morrice N, "et al." |title=Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. |journal=Biochem. J. |volume=352 Pt 1 |issue= |pages= 145–54 |year= 2001 |pmid= 11062067 |doi=
*cite journal | author=Vitale G, Bernardi L, Napolitani G, "et al." |title=Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. |journal=Biochem. J. |volume=352 Pt 3 |issue= |pages= 739–45 |year= 2001 |pmid= 11104681 |doi=
*cite journal | author=Chayama K, Papst PJ, Garrington TP, "et al." |title=Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 8 |pages= 4599–604 |year= 2001 |pmid= 11274363 |doi= 10.1073/pnas.081021898
*cite journal | author=Acierno JS, Kennedy JC, Falardeau JL, "et al." |title=A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2. |journal=Genomics |volume=73 |issue= 2 |pages= 203–10 |year= 2001 |pmid= 11318610 |doi= 10.1006/geno.2001.6526
*cite journal | author=Tournier C, Dong C, Turner TK, "et al." |title=MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. |journal=Genes Dev. |volume=15 |issue= 11 |pages= 1419–26 |year= 2001 |pmid= 11390361 |doi= 10.1101/gad.888501
*cite journal | author=Gross EA, Callow MG, Waldbaum L, "et al." |title=MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13873–82 |year= 2002 |pmid= 11836244 |doi= 10.1074/jbc.M111994200
*cite journal | author=Kawaguchi M, Onuchic LF, Huang SK |title=Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15229–32 |year= 2002 |pmid= 11891214 |doi= 10.1074/jbc.C100641200PBB_Controls
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