T-complex 1

T-complex 1, also known as TCP1, is a human gene.cite web | title = Entrez Gene: TCP1 t-complex 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6950| accessdate = ]

section_title =
summary_text = This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: TCP1 t-complex 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6950| accessdate = ]


Further reading

citations =
*cite journal | author=Horwich AL, Willison KR |title=Protein folding in the cell: functions of two families of molecular chaperone, hsp 60 and TF55-TCP1. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=339 |issue= 1289 |pages= 313–25; discussion 325–6 |year= 1993 |pmid= 8098536 |doi= 10.1098/rstb.1993.0030
*cite journal | author=Burston SG, Clarke AR |title=Molecular chaperones: physical and mechanistic properties. |journal=Essays Biochem. |volume=29 |issue= |pages= 125–36 |year= 1997 |pmid= 9189717 |doi=
*cite journal | author=Blanché H, Wright LG, Vergnaud G, "et al." |title=Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG. |journal=Genomics |volume=12 |issue= 4 |pages= 826–8 |year= 1992 |pmid= 1572657 |doi=
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Yaffe MB, Farr GW, Miklos D, "et al." |title=TCP1 complex is a molecular chaperone in tubulin biogenesis. |journal=Nature |volume=358 |issue= 6383 |pages= 245–8 |year= 1992 |pmid= 1630491 |doi= 10.1038/358245a0
*cite journal | author=Lewis VA, Hynes GM, Zheng D, "et al." |title=T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol. |journal=Nature |volume=358 |issue= 6383 |pages= 249–52 |year= 1992 |pmid= 1630492 |doi= 10.1038/358249a0
*cite journal | author=Ursic D, Culbertson MR |title=The yeast homolog to mouse Tcp-1 affects microtubule-mediated processes. |journal=Mol. Cell. Biol. |volume=11 |issue= 5 |pages= 2629–40 |year= 1991 |pmid= 1901944 |doi=
*cite journal | author=Kirchhoff C, Willison K |title=Nucleotide and amino-acid sequence of human testis-derived TCP1. |journal=Nucleic Acids Res. |volume=18 |issue= 14 |pages= 4247 |year= 1990 |pmid= 2377466 |doi=
*cite journal | author=Fonatsch C, Gradl G, Ragoussis J, Ziegler A |title=Assignment of the TCP1 locus to the long arm of human chromosome 6 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=45 |issue= 2 |pages= 109–12 |year= 1987 |pmid= 3476253 |doi=
*cite journal | author=Willison K, Kelly A, Dudley K, "et al." |title=The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. |journal=EMBO J. |volume=6 |issue= 7 |pages= 1967–74 |year= 1987 |pmid= 3653076 |doi=
*cite journal | author=Roobol A, Holmes FE, Hayes NV, "et al." |title=Cytoplasmic chaperonin complexes enter neurites developing in vitro and differ in subunit composition within single cells. |journal=J. Cell. Sci. |volume=108 ( Pt 4) |issue= |pages= 1477–88 |year= 1995 |pmid= 7615668 |doi=
*cite journal | author=Ashworth A |title=Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes. |journal=Genomics |volume=18 |issue= 2 |pages= 195–8 |year= 1994 |pmid= 7904580 |doi= 10.1006/geno.1993.1454
*cite journal | author=Miklos D, Caplan S, Mertens D, "et al." |title=Primary structure and function of a second essential member of the heterooligomeric TCP1 chaperonin complex of yeast, TCP1 beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 7 |pages= 2743–7 |year= 1994 |pmid= 7908441 |doi=
*cite journal | author=Chen X, Sullivan DS, Huffaker TC |title=Two yeast genes with similarity to TCP-1 are required for microtubule and actin function in vivo. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 19 |pages= 9111–5 |year= 1994 |pmid= 7916460 |doi=
*cite journal | author=Kubota H, Hynes G, Carne A, "et al." |title=Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. |journal=Curr. Biol. |volume=4 |issue= 2 |pages= 89–99 |year= 1994 |pmid= 7953530 |doi=
*cite journal | author=Frydman J, Hartl FU |title=Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms. |journal=Science |volume=272 |issue= 5267 |pages= 1497–502 |year= 1996 |pmid= 8633246 |doi=
*cite journal | author=Moudjou M, Bordes N, Paintrand M, Bornens M |title=gamma-Tubulin in mammalian cells: the centrosomal and the cytosolic forms. |journal=J. Cell. Sci. |volume=109 ( Pt 4) |issue= |pages= 875–87 |year= 1996 |pmid= 8718679 |doi=
*cite journal | author=Morrison K, Papapetrou C, Attwood J, "et al." |title=Genetic mapping of the human homologue (T) of mouse T(Brachyury) and a search for allele association between human T and spina bifida. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 669–74 |year= 1997 |pmid= 8733136 |doi=
*cite journal | author=Masuno M, Fukao T, Song XQ, "et al." |title=Assignment of the human cytosolic acetoacetyl-coenzyme A thiolase (ACAT2) gene to chromosome 6q25.3-q26. |journal=Genomics |volume=36 |issue= 1 |pages= 217–8 |year= 1997 |pmid= 8812443 |doi= 10.1006/geno.1996.0452

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