Microsomal triglyceride transfer protein

Microsomal triglyceride transfer protein
Microsomal triglyceride transfer protein
Identifiers
Symbols MTTP; ABL; MGC149819; MGC149820; MTP
External IDs OMIM157147 MGI106926 HomoloGene212 GeneCards: MTTP Gene
RNA expression pattern
PBB GE MTTP 205675 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4547 17777
Ensembl ENSG00000138823 ENSMUSG00000028158
UniProt P55157 Q3TVF2
RefSeq (mRNA) NM_000253 NM_008642
RefSeq (protein) NP_000244 NP_032668
Location (UCSC) Chr 4:
100.48 – 100.55 Mb
Chr 3:
137.75 – 137.81 Mb
PubMed search [1] [2]

Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene.[1][2]

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.[2]

Apoprotein B48 on chylomicra and Apoprotein B100 on LDL, IDL, and VLDL are important for MTP binding.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[3]

[[File:
StatinPathway_WP430 go to article search for article go to article search for article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article Go to article Go to article Go to article Go to KEGG Go to KEGG Go to KEGG Go to article Go to KEGG Go to KEGG Go to KEGG Go to KEGG go to article go to article go to article Go to article go to article go to article go to article Go to KEGG Go to article search for article search for article Go to HMDB search for article search for article Go to article go to article
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
[[ ]]
StatinPathway_WP430 go to article search for article go to article search for article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article Go to article Go to article Go to article Go to KEGG Go to KEGG Go to KEGG Go to article Go to KEGG Go to KEGG Go to KEGG Go to KEGG go to article go to article go to article Go to article go to article go to article go to article Go to KEGG Go to article search for article search for article Go to HMDB search for article search for article Go to article go to article
|{{{bSize}}}px]]
Statin Pathway edit

References

  1. ^ Shoulders CC, Brett DJ, Bayliss JD, Narcisi TM, Jarmuz A, Grantham TT, Leoni PR, Bhattacharya S, Pease RJ, Cullen PM, et al. (Mar 1994). "Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein". Hum Mol Genet 2 (12): 2109–16. doi:10.1093/hmg/2.12.2109. PMID 8111381. 
  2. ^ a b "Entrez Gene: MTTP microsomal triglyceride transfer protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4547. 
  3. ^ The interactive pathway map can be edited at WikiPathways: "StatinPathway_WP430". http://www.wikipathways.org/index.php/Pathway:WP430. 

Further reading



Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • microsomal triglyceride transfer protein — (MTP) a protein that occurs in the lumen of the endoplasmic reticulum and is responsible for the transfer of triglycerides and other lipids from the endoplasmic reticulum, where they are synthesized, into the lumen during the assembly of very low …   Medical dictionary

  • Abetalipoproteinemia — Classification and external resources Micrograph showing enterocytes with a clear cytoplasm (due to lipid accumulation) characteristic of abetalipoproteinemia. Duodenal bi …   Wikipedia

  • Mikrosomales Triglycerid-Transferprotein — Das mikrosomale Triglycerid Transferprotein (MTP) ist ein Proteinkomplex aus zwei Proteinen, der im endoplasmatischen Reticulum (ER) aller Säugetiere lokalisiert ist. MTP katalysiert den Transport und Einbau von Triglyceriden, Cholesterinestern,… …   Deutsch Wikipedia

  • Familial hypercholesterolemia — Classification and external resources Xanthelasma palpebrarum, yellowish patches consisting of cholesterol deposits above the eyelids. These are more common in people with FH. ICD …   Wikipedia

  • P4HB — Prolyl 4 hydroxylase, beta polypeptide PDB rendering based on 1bjx …   Wikipedia

  • MTP — maximum tolerated pressure; medial tibial plateau; median time to progression; metatarsophalangeal; micropayment transfer protocol; microsomal triglyceride transfer protein; microtubule protein * * * microsomal triglyceride transfer protein …   Medical dictionary

  • Lomitapid — Strukturformel Allgemeines Freiname Lomitapid Andere Namen …   Deutsch Wikipedia

  • ДИСБЕТАЛИПОПРОТЕИНЕМИИ — мед. Абеталипопротеинемия в крови нет р липопротеинов, хиломикронов, липопротеинов с плотностью ниже 1,063 (ЛНП и ЛОНП), эритроциты имеют множественные шиловидные выросты (акантоциты), развивается дефицит витаминов Е и А (результат отсутствия ЛНП …   Справочник по болезням

  • MTP — is an abbreviation with several meanings:Medicine: * Medial tibial plateau, at the upper end of the tibia * Medical termination of pregnancy * Metatarsophalangeal joint, between the foot and the toe * Microsomal triglyceride transfer protein a… …   Wikipedia

  • AP-1 (transcription factor) — In molecular biology, the activator protein 1 (AP 1) is a transcription factor which is a heterodimeric protein composed of proteins belonging to the c Fos, c Jun, ATF and JDP families. AP 1 upregulates transcription of genes containing the TPA… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”