- NDRG1
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N-myc downstream regulated 1 Identifiers Symbols NDRG1; CAP43; CMT4D; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5 External IDs OMIM: 605262 MGI: 1341799 HomoloGene: 55953 GeneCards: NDRG1 Gene Gene Ontology Molecular function • protein binding Cellular component • nucleus
• cytoplasm
• plasma membrane
• microtubule cytoskeletonBiological process • response to metal ion
• mast cell activation
• cellular response to hypoxiaSources: Amigo / QuickGO RNA expression pattern 
More reference expression data Orthologs Species Human Mouse Entrez 10397 17988 Ensembl ENSG00000104419 ENSMUSG00000005125 UniProt Q92597 n/a RefSeq (mRNA) NM_001135242.1 NM_008681.2 RefSeq (protein) NP_001128714.1 NP_032707.2 Location (UCSC) Chr 8:
134.25 – 134.31 MbChr 15:
66.76 – 66.8 MbPubMed search [1] [2] Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.[1][2][3][4]
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom.[4] It has been reported that NDRG1 localizes to the endosomes and is a Rab4a effector involved in vesicular recycling.[5]
References
- ^ van Belzen N, Dinjens WN, Diesveld MP, Groen NA, van der Made AC, Nozawa Y, Vlietstra R, Trapman J, Bosman FT (Sep 1997). "A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms". Lab Invest 77 (1): 85–92. PMID 9251681.
- ^ Kokame K, Kato H, Miyata T (Jan 1997). "Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes". J Biol Chem 271 (47): 29659–65. doi:10.1074/jbc.271.47.29659. PMID 8939898.
- ^ Zhang J, Chen S, Zhang W, Zhang J, Liu X, Shi H, Che H, Wang W, Li F, Yao L (Jun 2008). "Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region". Gene 417 (1-2): 5–12. doi:10.1016/j.gene.2008.03.002. PMID 18455888.
- ^ a b "Entrez Gene: NDRG1 N-myc downstream regulated gene 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10397.
- ^ Kachhap SK, Faith D, Qian DZ, et al. (2007). Heisenberg, Carl-Philipp. ed. "The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin". PLoS ONE 2 (9): e844. doi:10.1371/journal.pone.0000844. PMC 1952073. PMID 17786215. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1952073.
Further reading
- Kovacevic Z, Richardson DR (2007). "The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer.". Carcinogenesis 27 (12): 2355–66. doi:10.1093/carcin/bgl146. PMID 16920733.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Kalaydjieva L, Hallmayer J, Chandler D, et al. (1996). "Gene mapping in Gypsies identifies a novel demyelinating neuropathy on chromosome 8q24.". Nat. Genet. 14 (2): 214–7. doi:10.1038/ng1096-214. PMID 8841199.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Zhou D, Salnikow K, Costa M (1998). "Cap43, a novel gene specifically induced by Ni2+ compounds.". Cancer Res. 58 (10): 2182–9. PMID 9605764.
- Kurdistani SK, Arizti P, Reimer CL, et al. (1998). "Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage.". Cancer Res. 58 (19): 4439–44. PMID 9766676.
- Piquemal D, Joulia D, Balaguer P, et al. (1999). "Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells.". Biochim. Biophys. Acta 1450 (3): 364–73. doi:10.1016/S0167-4889(99)00056-7. PMID 10395947.
- Guan RJ, Ford HL, Fu Y, et al. (2000). "Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer.". Cancer Res. 60 (3): 749–55. PMID 10676663.
- Kalaydjieva L, Gresham D, Gooding R, et al. (2000). "N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom.". Am. J. Hum. Genet. 67 (1): 47–58. doi:10.1086/302978. PMC 1287101. PMID 10831399. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1287101.
- Park H, Adams MA, Lachat P, et al. (2000). "Hypoxia induces the expression of a 43-kDa protein (PROXY-1) in normal and malignant cells.". Biochem. Biophys. Res. Commun. 276 (1): 321–8. doi:10.1006/bbrc.2000.3475. PMID 11006124.
- Rutherford MN, Bayly GR, Matthews BP, et al. (2001). "The leukemogenic transcription factor E2a-Pbx1 induces expression of the putative N-myc and p53 target gene NDRG1 in Ba/F3 cells.". Leukemia 15 (3): 362–70. doi:10.1038/sj.leu.2402059. PMID 11237058.
- Zhou RH, Kokame K, Tsukamoto Y, et al. (2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart.". Genomics 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569.
- Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.". Mol. Cell. Biochem. 229 (1-2): 35–44. doi:10.1023/A:1017934810825. PMID 11936845.
- Cangul H, Salnikow K, Yee H, et al. (2002). "Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis.". Cell Biol. Toxicol. 18 (2): 87–96. doi:10.1023/A:1015376032736. PMID 12046693.
- Cangul H, Salnikow K, Yee H, et al. (2002). "Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells.". Environ. Health Perspect. 110 Suppl 5: 783–8. PMC 1241245. PMID 12429530. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1241245.
- Lachat P, Shaw P, Gebhard S, et al. (2003). "Expression of NDRG1, a differentiation-related gene, in human tissues.". Histochem. Cell Biol. 118 (5): 399–408. doi:10.1007/s00418-002-0460-9. PMID 12432451.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Segawa T, Nau ME, Xu LL, et al. (2003). "Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells.". Oncogene 21 (57): 8749–58. doi:10.1038/sj.onc.1205992. PMID 12483528.
External links
Categories:- Human proteins
- Chromosome 8 gene stubs
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