5-hydroxyeicosatetraenoic acid

5-hydroxyeicosatetraenoic acid

5-hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid.

Functions

5-HETE is a step in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback.


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  • hydroxyeicosatetraenoic acid — (HETE) hy·droxy·ei·co·sa·tet·ra·eno·ic ac·id (HETE) (hi drok″se i ko″sə tet″rə e noґik) any of several arachidonic acid metabolites produced by lipoxygenases from hydroperoxyeicosatetraenoic acid. 5 HETE is a byproduct …   Medical dictionary

  • hydroxyeicosatetraenoic acid — noun A hydroxy derivative of a polyunsaturated fatty acid; it is an intermediate in the biosynthesis of leukotrienes …   Wiktionary

  • arachidonic acid — (= 5,8,11,14 eicosatetraenoic acid) An essential dietary component for mammals. The free acid is the precursor for biosynthesis of the signalling molecules prostaglandins, thromboxanes, hydroxyeicosatetraenoic acid derivatives including… …   Dictionary of molecular biology

  • HETE — hydroxyeicosatetraenoic [acid] * * * hydroxyeicosatetraenoic acid …   Medical dictionary

  • HETE — Hydroxyeicosatetraenoic acid (Ácido hidroxieicosatetraenoico) …   Diccionario de siglas médicas y otras abreviaturas

  • HETE — • hydroxyeicosatetraenoic [acid] …   Dictionary of medical acronyms & abbreviations

  • lipoxygenase pathway — a pathway for the formation of leukotrienes and hydroxyeicosatetraenoic acids from arachidonic acid. It is initiated by oxidation of arachidonic acid by arachidonate lipoxygenases, and the reactions occur in the cytosol of leukocytes, mast cells …   Medical dictionary

  • CYP4A11 — Cytochrome P450, family 4, subfamily A, polypeptide 11, also known as CYP4A11, is a human gene.cite web | title = Entrez Gene: CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Leukotriene — Leukotrienes are naturally produced eicosanoid lipid mediators, which may be responsible for the effects of an inflammatory response. Leukotrienes use both autocrine signalling and paracrine signalling to regulate the body s response.… …   Wikipedia

  • Arachidonate 5-lipoxygenase — (5 lipoxygenase, 5 LO or Alox5) is a human enzyme, member of the lipoxygenase family. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.ubstrates and productsEFA substrates and… …   Wikipedia

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