4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
- 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
In enzymology, a 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (EC number|2.7.1.148) is an enzyme that catalyzes the chemical reaction
:ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
Thus, the two substrates of this enzyme are ATP and 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, whereas its two products are ADP and 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase. This enzyme is also called CDP-ME kinase. This enzyme participates in biosynthesis of steroids.
tructural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1OJ4, PDB link|1UEK, PDB link|2V2Q, PDB link|2V2V, PDB link|2V2Z, PDB link|2V34, and PDB link|2V8P.
References
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External links
Gene Ontology (GO) codes
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