2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

In enzymology, a 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (EC number|2.7.6.3) is an enzyme that catalyzes the chemical reaction

:ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine $ightleftharpoons$ AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate

Thus, the two substrates of this enzyme are ATP and 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine, whereas its two products are AMP and (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring two phosphorus-containing groups (diphosphotransferases). The systematic name of this enzyme class is ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase. Other names in common use include 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, H2-pteridine-CH2OH pyrophosphokinase, 7,8-dihydroxymethylpterin-pyrophosphokinase, HPPK, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase, and hydroxymethyldihydropteridine pyrophosphokinase. This enzyme participates in folate biosynthesis.

tructural studies

As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DY3, PDB link|1EQ0, PDB link|1EQM, PDB link|1EX8, PDB link|1F9H, PDB link|1F9Y, PDB link|1G4C, PDB link|1HKA, PDB link|1HQ2, PDB link|1IM6, PDB link|1KBR, PDB link|1Q0N, PDB link|1RAO, PDB link|1RB0, PDB link|1RTZ, PDB link|1RU1, PDB link|1RU2, PDB link|1TMJ, PDB link|1TMM, PDB link|2BMB, PDB link|2CG8, PDB link|2F63, and PDB link|2F65.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37278-23-2."

Gene Ontology (GO) codes