Dolichyl-phosphate-mannose-protein mannosyltransferase

dolichyl-phosphate-mannose-protein mannosyltransferase
Identifiers
EC number	2.4.1.109
CAS number	74315-99-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a dolichyl-phosphate-mannose-protein mannosyltransferase (EC 2.4.1.109) is an enzyme that catalyzes the chemical reaction

dolichyl phosphate D-mannose + protein $\rightleftharpoons$ dolichyl phosphate + O-D-mannosylprotein

Thus, the two substrates of this enzyme are dolichyl phosphate D-mannose and protein, whereas its two products are dolichyl phosphate and O-D-mannosylprotein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase. Other names in common use include dolichol phosphomannose-protein mannosyltransferase, and protein O-D-mannosyltransferase. A human gene that codes for this enzyme is POMT1.

References

• Babczinski P, Haselbeck A, Tanner W (1980). "Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme". Eur. J. Biochem. 105 (3): 509–15. doi:10.1111/j.1432-1033.1980.tb04526.x. PMID 6989607. 
• Palamarczyk G, Lehle L, Mankowski T, Chojnacki T, Tanner W (1980). "Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives". Eur. J. Biochem. 105 (3): 517–23. doi:10.1111/j.1432-1033.1980.tb04527.x. PMID 6445267. 

2.4.2: Pentosyl-
transferases

Ribose	ADP-ribosyltransferase NAD+:diphthamide ADP-ribosyltransferase (Diphtheria toxin) NAD(P)+:arginine ADP-ribosyltransferase (Pertussis toxin · Cholera toxin) Poly ADP ribose polymerase Sirtuin Phosphoribosyltransferase Adenine phosphoribosyltransferase · Hypoxanthine-guanine phosphoribosyltransferase · Uracil phosphoribosyltransferase · Amidophosphoribosyltransferase Other Purine nucleoside phosphorylase: Thymidine phosphorylase (ECGF1)
Other	Xylosyltransferase · Arabinosyltransferase (Indolylacetylinositol arabinosyltransferase)

2.4.99: Sialyl
transferases

Beta-galactoside alpha-2,6-sialyltransferase · Monosialoganglioside sialyltransferase · ST8SIA4

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6