Retinal G protein coupled receptor

Retinal G protein coupled receptor

Retinal G protein coupled receptor, also known as RGR, is a human gene.cite web | title = Entrez Gene: RGR retinal G protein coupled receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5995| accessdate = ]

PBB_Summary
section_title =
summary_text = Defects in this gene are a cause of retinitis pigmentosa. The gene is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein presumably acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: RGR retinal G protein coupled receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5995| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jiang M, Shen D, Tao L, "et al." |title=Alternative splicing in human retinal mRNA transcripts of an opsin-related protein. |journal=Exp. Eye Res. |volume=60 |issue= 4 |pages= 401–6 |year= 1995 |pmid= 7789419 |doi=
*cite journal | author=Shen D, Jiang M, Hao W, "et al." |title=A human opsin-related gene that encodes a retinaldehyde-binding protein. |journal=Biochemistry |volume=33 |issue= 44 |pages= 13117–25 |year= 1994 |pmid= 7947717 |doi=
*cite journal | author=Chen XN, Korenberg JR, Jiang M, "et al." |title=Localization of the human RGR opsin gene to chromosome 10q23. |journal=Hum. Genet. |volume=97 |issue= 6 |pages= 720–2 |year= 1996 |pmid= 8641686 |doi=
*cite journal | author=Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP |title=Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. |journal=Nat. Genet. |volume=23 |issue= 4 |pages= 393–4 |year= 1999 |pmid= 10581022 |doi= 10.1038/70496
*cite journal | author=Chen P, Lee TD, Fong HK |title=Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21098–104 |year= 2001 |pmid= 11274198 |doi= 10.1074/jbc.M010441200
*cite journal | author=Yang M, Fong HK |title=Synthesis of the all-trans-retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3318–24 |year= 2002 |pmid= 11723126 |doi= 10.1074/jbc.M108946200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bellingham J, Wells DJ, Foster RG |title=In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution. |journal=BMC Genomics |volume=4 |issue= 1 |pages= 3 |year= 2003 |pmid= 12542842 |doi=
*cite journal | author=Tarttelin EE, Bellingham J, Bibb LC, "et al." |title=Expression of opsin genes early in ocular development of humans and mice. |journal=Exp. Eye Res. |volume=76 |issue= 3 |pages= 393–6 |year= 2003 |pmid= 12573668 |doi=
*cite journal | author=Bernal S, Calaf M, Garcia-Hoyos M, "et al." |title=Study of the involvement of the RGR, CRPB1, and CRB1 genes in the pathogenesis of autosomal recessive retinitis pigmentosa. |journal=J. Med. Genet. |volume=40 |issue= 7 |pages= e89 |year= 2003 |pmid= 12843338 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Zhu L, Imanishi Y, Filipek S, "et al." |title=Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. |journal=J. Biol. Chem. |volume=281 |issue= 31 |pages= 22289–98 |year= 2006 |pmid= 16737970 |doi= 10.1074/jbc.M602664200
*cite journal | author=Lin MY, Kochounian H, Moore RE, "et al." |title=Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane. |journal=Mol. Vis. |volume=13 |issue= |pages= 1203–14 |year= 2007 |pmid= 17679941 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • G protein-coupled receptor — G protein coupled receptors (GPCRs), also known as seven transmembrane domain receptors, 7TM receptors, heptahelical receptors, and G protein linked receptors (GPLR), comprise a large protein family of transmembrane receptors that sense molecules …   Wikipedia

  • Retinylidene protein — Retinylidene proteins are a family of proteins that use retinal as chromophore for light reception. This group of proteins is also commonly referred to as rhodopsins. They are the molecular basis for a variety of light sensing systems from… …   Wikipedia

  • G-Protein-gekoppelter Rezeptor — Bändermodell des G Protein gekoppelten Rezeptors Rhodopsin …   Deutsch Wikipedia

  • GABA receptor — The GABA receptors are a class of receptors that respond to the neurotransmitter γ aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are three classes of GABA receptors: GABAA, GABAB,… …   Wikipedia

  • RRH — Retinal pigment epithelium derived rhodopsin homolog, also known as RRH, is a human gene.cite web | title = Entrez Gene: RRH retinal pigment epithelium derived rhodopsin homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Opsin — Three dimensional structure of bovine rhodopsin. The seven transmembrane domains are shown in varying colors. The chromophore is shown in red. Opsins are a group of light sensitive 35–55 kDa membrane bound G protein coupled receptors of the… …   Wikipedia

  • Rhodopsin-like receptors — Pfam box Symbol = 7tm 1 Name = Rhodopsin like receptors width = caption = Pfam= PF00001 InterPro= IPR000276 SMART= PROSITE = PDOC00211 SCOP = 1f88 TCDB = OPM family= 6 OPM protein= 1gzm PDB=Rhodopsin like receptors are the largest group of G… …   Wikipedia

  • OPN5 — Opsin 5 Identifiers Symbols OPN5; GPR136; PGR12; TMEM13 External IDs OMIM:  …   Wikipedia

  • RDH5 — Retinol dehydrogenase 5 (11 cis/9 cis), also known as RDH5, is a human gene.cite web | title = Entrez Gene: RDH5 retinol dehydrogenase 5 (11 cis/9 cis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5959|… …   Wikipedia

  • RGR — Sturm Ruger & Company, Inc. (Business » NYSE Symbols) * Ranger Regiment (Governmental » Military) * RetroGaming Radio (Community » Media) * RetroGaming Radio (Community » Sports) * RPE Retinal G Protein Coupled Receptor (Medical » Human Genome) * …   Abbreviations dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”