Muscle type nicotinic receptor
- Muscle type nicotinic receptor
The muscle type nicotinic receptor is a type of nicotinic acetylcholine receptor, consisting of the subunit combination (α1)2β1δε[ Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 138. ] .]It is located in the neuromuscular junction, where activation yields EPSP, mainly by increased Na+ and K+ permeability.
Agonists
Nicotinic agonists for this receptor include:
*acetylcholine
*carbachol
*suxamethonium
Antagonists
*α-bungarotoxin [ [http://www.neurosci.pharm.utoledo.edu/MBC3320/nicotinic.htm Neurosci.pharm - MBC 3320 Acetylcholine] ] ]
*α-conotoxin
*tubocurarine
*pancuronium
*hexamethoniumReferences
Wikimedia Foundation.
2010.
Look at other dictionaries:
Muscle-type nicotinic receptor — The muscle type nicotinic receptor is a type of nicotinic acetylcholine receptor, consisting of the subunit combination (α1)2β1δε or (α1)2β1δγ.[1] It is located in the neuromuscular junction, where activation yields EPSP, mainly by increased Na+… … Wikipedia
nicotinic receptor — a type of cholinergic receptor that is stimulated initially and blocked at high doses by the alkaloid nicotine and blocked by tubocurarine. These receptors are acetylcholine gated ion channels and are found on autonomic ganglion cells, striated… … Medical dictionary
Nicotinic acetylcholine receptor — Acetylcholine Nicotine … Wikipedia
Nicotinic agonist — A nicotinic agonist is a drug which enhances the action at the nicotinic acetylcholine receptor (nAChR). Examples include: nicotine (by definition the nicotinic acetylcholine receptor is named for its affinity for nicotine) acetylcholine, the… … Wikipedia
Nicotinic antagonist — A nicotinic antagonist is a type of anticholinergic that inhibits the action at nicotinic acetylcholine receptors. These compounds are mainly used for peripheral muscle paralysis in surgery, but some centrally acting compounds such as bupropion,… … Wikipedia
Muscle contraction — See also: Twitch and Tremor Top down view of skeletal muscle Muscle fiber generates tension through the action of actin and myosin cross bridge cycling. While under tension, the muscle may lengthen, shorten, or … Wikipedia
Receptor — In cell biology, a structure on the surface of a cell (or inside a cell) that selectively receives and binds a specific substance. There are hoards of receptors. There are receptors for insulin, receptors for low density lipoproteins (LDL), etc.… … Medical dictionary
Receptor (biochemistry) — For other uses, see Receptor (disambiguation). In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism. These signals… … Wikipedia
Acetylcholine receptor — Acetylcholine An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter. Contents … Wikipedia
Cell surface receptor — The seven transmembrane α helix structure of a G protein coupled receptor Cell surface receptors (membrane receptors, transmembrane receptors) are specialized integral membrane proteins that take part in communication between the cell and the… … Wikipedia
