Leukotriene B4 receptor 2

Leukotriene B4 receptor 2

Leukotriene B4 receptor 2, also known as LTB4R2, is a human gene.cite web | title = Entrez Gene: LTB4R2 leukotriene B4 receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56413| accessdate = ]

This is a low-affinity receptor for leukotrienes, especially leukotriene B4. It mediates chemotaxis of granulocytes and macrophages.

PBB_Summary
section_title =
summary_text =

ee also

* Eicosanoid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tager AM, Luster AD |title=BLT1 and BLT2: the leukotriene B(4) receptors. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=69 |issue= 2-3 |pages= 123–34 |year= 2004 |pmid= 12895595 |doi=
*cite journal | author=Kamohara M, Takasaki J, Matsumoto M, "et al." |title=Molecular cloning and characterization of another leukotriene B4 receptor. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27000–4 |year= 2000 |pmid= 10889186 |doi= 10.1074/jbc.C000382200
*cite journal | author=Tryselius Y, Nilsson NE, Kotarsky K, "et al." |title=Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 2 |pages= 377–82 |year= 2000 |pmid= 10913346 |doi= 10.1006/bbrc.2000.3152
*cite journal | author=Nilsson NE, Tryselius Y, Owman C |title=Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 2 |pages= 383–8 |year= 2000 |pmid= 10913347 |doi= 10.1006/bbrc.2000.3153
*cite journal | author=Kato K, Yokomizo T, Izumi T, Shimizu T |title=Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 413–20 |year= 2000 |pmid= 10934229 |doi=
*cite journal | author=Yokomizo T, Kato K, Terawaki K, "et al." |title=A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 421–32 |year= 2000 |pmid= 10934230 |doi=
*cite journal | author=Wang S, Gustafson E, Pang L, "et al." |title=A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. |journal=J. Biol. Chem. |volume=275 |issue= 52 |pages= 40686–94 |year= 2001 |pmid= 11006272 |doi= 10.1074/jbc.M004512200
*cite journal | author=Takeda S, Kadowaki S, Haga T, "et al." |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hashimoto A, Endo H, Hayashi I, "et al." |title=Differential expression of leukotriene B4 receptor subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid leukocytes of patients with rheumatoid arthritis. |journal=J. Rheumatol. |volume=30 |issue= 8 |pages= 1712–8 |year= 2003 |pmid= 12913925 |doi=
*cite journal | author=Yoo MH, Song H, Woo CH, "et al." |title=Role of the BLT2, a leukotriene B4 receptor, in Ras transformation. |journal=Oncogene |volume=23 |issue= 57 |pages= 9259–68 |year= 2005 |pmid= 15489890 |doi= 10.1038/sj.onc.1208151
*cite journal | author=Qiu H, Johansson AS, Sjöström M, "et al." |title=Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 18 |pages= 6913–8 |year= 2006 |pmid= 16624877 |doi= 10.1073/pnas.0602208103
*cite journal | author=Lundeen KA, Sun B, Karlsson L, Fourie AM |title=Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells. |journal=J. Immunol. |volume=177 |issue= 5 |pages= 3439–47 |year= 2006 |pmid= 16920986 |doi=

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1289 IUPHAR GPCR Database - Leukotriene receptors]
*
*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Leukotriene B4 receptor — Leukotriene B4 receptor, also known as LTB4R, is a human gene.cite web | title = Entrez Gene: LTB4R leukotriene B4 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1241| accessdate = ] PBB Summary… …   Wikipedia

  • Leukotriene — Leukotrienes are naturally produced eicosanoid lipid mediators, which may be responsible for the effects of an inflammatory response. Leukotrienes use both autocrine signalling and paracrine signalling to regulate the body s response.… …   Wikipedia

  • Leukotriene antagonist — A leukotriene antagonist is a hormone antagonist acting upon leukotrienes.It has been demonstrated that leukotrienes are implicated in bronchoconstriction and in the inflammatory cascade leading to asthma. Leukotriene modifiers are an important… …   Wikipedia

  • leukotriene receptor antagonist — any of a class of antiasthmatic drugs that bind competitively to leukotriene receptors in the airways, thus inhibiting bronchoconstriction caused by leukotriene mediated inflammatory response …   Medical dictionary

  • leukotriene modifier — any of a group of antiasthmatic agents that act by inhibiting the formation or activity of leukotrienes; the major types are the leukotriene receptor antagonists and the leukotriene pathway modifiers …   Medical dictionary

  • leukotriene receptor antagonist — one of a class of drugs that prevent the action of leukotriene by blocking their receptors on cell membranes, such as those in the airways. These drugs are used in the treatment of asthma for their effects in relaxing the smooth muscle of the… …   Medical dictionary

  • Cysteinyl leukotriene receptor 1 — Identifiers Symbols CYSLTR1; CYSLT1; CYSLT1R; CYSLTR; HG55; HMTMF81; MGC46139 External IDs …   Wikipedia

  • Cysteinyl leukotriene receptor 2 — Identifiers Symbols CYSLTR2; CYSLT2; CYSLT2R; HG57; HPN321; KPG 011; hGPCR21 External IDs …   Wikipedia

  • Eicosanoid receptor — An eicosanoid receptor is an integral membrane protein which detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein coupled receptors (GPCRs). An example of a non GPCR receptor that binds eicosanoids is PPAR γ …   Wikipedia

  • leukotriene receptor antagonist — one of a class of drugs that prevent the action of leukotrienes by blocking their receptors on cell membranes, such as those in the airways. These drugs are used in the management of asthma for their effects in relaxing the smooth muscle of the… …   The new mediacal dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”