- Membrane-bound transcription factor peptidase, site 1
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membrane-bound transcription factor peptidase, site 1 Identifiers Symbol MBTPS1 Alt. symbols S1P Entrez 8720 HUGO 15456 OMIM 603355 RefSeq NM_003791 UniProt Q14703 Other data EC number 3.4.21.112 Locus Chr. 16 q24 Membrane-bound transcription factor peptidase, site 1 also known as Site-1 Protease (S1P) is an enzyme (EC 3.4.21.112) encoded by the MBTPS1 gene which cleaves the endoplasmic reticulum loop of sterol regulatory element binding protein (SREBP) transcription factors.[1][2]
See also
References
- ^ Brown MS, Goldstein JL (1999). "A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11041–8. doi:10.1073/pnas.96.20.11041. PMC 34238. PMID 10500120. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=34238.
- ^ Nakajima T, Iwaki K, Kodama T, Inazawa J, Emi M (2000). "Genomic structure and chromosomal mapping of the human site-1 protease (S1P) gene". J. Hum. Genet. 45 (4): 212–7. doi:10.1007/s100380070029. PMID 10944850.
External links
Digestive enzymes Coagulation factors: Thrombin · Factor VIIa · Factor IXa · Factor Xa · Factor XIa · Factor XIIa · Kallikrein (PSA, KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK12, KLK13, KLK14, KLK15)
fibrinolysis: Plasmin · Plasminogen activator (Tissue plasminogen activator · Urinary plasminogen activator)Complement system Other immune system Venombin Other Acrosin · Prolyl endopeptidase · Pronase · Proprotein convertases (1, 2) · Reelin · Subtilisin/Furin · Streptokinase · S1P · Cathepsin (A, G)B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6 Categories:- Genes on chromosome 16
- Chromosome 16 gene stubs
- EC 3.4.21
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