UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase

In enzymology, an UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase (EC number|6.3.2.9) is an enzyme that catalyzes the chemical reaction

:ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate $ightleftharpoons$ ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate

The 3 substrates of this enzyme are ATP, UDP-N-acetylmuramoyl-L-alanine, and D-glutamate, whereas its 3 products are ADP, phosphate, and UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (ADP-forming). Other names in common use include MurD synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase, D-glutamate-adding enzyme, D-glutamate ligase, UDP-Mur-NAC-L-Ala:D-Glu ligase, UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming), and UDP-N-acetylmuramoylalanine-D-glutamate ligase. This enzyme participates in d-glutamine and d-glutamate metabolism and peptidoglycan biosynthesis.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1E0D, PDB link|1EEH, PDB link|1UAG, PDB link|2JFF, PDB link|2JFG, PDB link|2JFH, PDB link|2UAG, PDB link|3UAG, and PDB link|4UAG.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-59-0."

Gene Ontology (GO) codes