SLC29A1

Solute carrier family 29 (nucleoside transporters), member 1, also known as SLC29A1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.cite web | title = Entrez Gene: SLC29A1 solute carrier family 29 (nucleoside transporters), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2030| accessdate = ]

ee also

* Solute carrier family

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Griffiths M, Beaumont N, Yao SY, "et al." |title=Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. |journal=Nat. Med. |volume=3 |issue= 1 |pages= 89–93 |year= 1997 |pmid= 8986748 |doi=
*cite journal | author=Coe IR, Griffiths M, Young JD, "et al." |title=Assignment of the human equilibrative nucleoside transporter (hENT1) to 6p21.1-p21.2. |journal=Genomics |volume=45 |issue= 2 |pages= 459–60 |year= 1998 |pmid= 9344680 |doi= 10.1006/geno.1997.4928
*cite journal | author=Griffiths M, Yao SY, Abidi F, "et al." |title=Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. |journal=Biochem. J. |volume=328 ( Pt 3) |issue= |pages= 739–43 |year= 1998 |pmid= 9396714 |doi=
*cite journal | author=Lum PY, Ngo LY, Bakken AH, Unadkat JD |title=Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles. |journal=Cancer Chemother. Pharmacol. |volume=45 |issue= 4 |pages= 273–8 |year= 2000 |pmid= 10755314 |doi=
*cite journal | author=Sundaram M, Yao SY, Ingram JC, "et al." |title=Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45270–5 |year= 2002 |pmid= 11584005 |doi= 10.1074/jbc.M107169200
*cite journal | author=SenGupta DJ, Lum PY, Lai Y, "et al." |title=A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine. |journal=Biochemistry |volume=41 |issue= 5 |pages= 1512–9 |year= 2002 |pmid= 11814344 |doi=
*cite journal | author=Yao SY, Ng AM, Vickers MF, "et al." |title=Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24938–48 |year= 2002 |pmid= 12006583 |doi= 10.1074/jbc.M200966200
*cite journal | author=Galmarini CM, Thomas X, Calvo F, "et al." |title=Potential mechanisms of resistance to cytarabine in AML patients. |journal=Leuk. Res. |volume=26 |issue= 7 |pages= 621–9 |year= 2002 |pmid= 12008078 |doi=
*cite journal | author=Lai Y, Bakken AH, Unadkat JD |title=Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37711–7 |year= 2002 |pmid= 12097333 |doi= 10.1074/jbc.M204986200
*cite journal | author=Sankar N, Machado J, Abdulla P, "et al." |title=Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity. |journal=Nucleic Acids Res. |volume=30 |issue= 20 |pages= 4339–50 |year= 2002 |pmid= 12384580 |doi=
*cite journal | author=Reiman T, Clarke ML, Dabbagh L, "et al." |title=Differential expression of human equilibrative nucleoside transporter 1 (hENT1) protein in the Reed-Sternberg cells of Hodgkin's disease. |journal=Leuk. Lymphoma |volume=43 |issue= 7 |pages= 1435–40 |year= 2003 |pmid= 12389626 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mangravite LM, Xiao G, Giacomini KM |title=Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. |journal=Am. J. Physiol. Renal Physiol. |volume=284 |issue= 5 |pages= F902–10 |year= 2003 |pmid= 12527552 |doi= 10.1152/ajprenal.00215.2002
*cite journal | author=Szkotak AJ, Ng AM, Man SF, "et al." |title=Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells. |journal=J. Membr. Biol. |volume=192 |issue= 3 |pages= 169–79 |year= 2003 |pmid= 12820662 |doi=
*cite journal | author=Lai Y, Tse CM, Unadkat JD |title=Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4490–7 |year= 2004 |pmid= 14607828 |doi= 10.1074/jbc.M307938200
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Endres CJ, Sengupta DJ, Unadkat JD |title=Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1. |journal=Biochem. J. |volume=380 |issue= Pt 1 |pages= 131–7 |year= 2004 |pmid= 14759222 |doi= 10.1042/BJ20031880
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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