CAMK4

CAMK4

Calcium/calmodulin-dependent protein kinase IV, also known as CAMK4, is a human gene.

PBB_Summary
section_title =
summary_text = The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.cite web | title = Entrez Gene: CAMK4 calcium/calmodulin-dependent protein kinase IV| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=814| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bredt DS, Ferris CD, Snyder SH |title=Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. |journal=J. Biol. Chem. |volume=267 |issue= 16 |pages= 10976–81 |year= 1992 |pmid= 1375933 |doi=
*cite journal | author=Jensen KF, Ohmstede CA, Fisher RS, Sahyoun N |title=Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 7 |pages= 2850–3 |year= 1991 |pmid= 2011593 |doi=
*cite journal | author=Sikela JM, Law ML, Kao FT, "et al." |title=Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV. |journal=Genomics |volume=4 |issue= 1 |pages= 21–7 |year= 1989 |pmid= 2536634 |doi=
*cite journal | author=Selbert MA, Anderson KA, Huang QH, "et al." |title=Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation. |journal=J. Biol. Chem. |volume=270 |issue= 29 |pages= 17616–21 |year= 1995 |pmid= 7615569 |doi=
*cite journal | author=Kitani T, Okuno S, Fujisawa H |title=cDNA cloning and expression of human calmodulin-dependent protein kinase IV. |journal=J. Biochem. |volume=115 |issue= 4 |pages= 637–40 |year= 1994 |pmid= 8089075 |doi=
*cite journal | author=Mosialos G, Hanissian SH, Jawahar S, "et al." |title=A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. |journal=J. Virol. |volume=68 |issue= 3 |pages= 1697–705 |year= 1994 |pmid= 8107230 |doi=
*cite journal | author=Bland MM, Monroe RS, Ohmstede CA |title=The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus. |journal=Gene |volume=142 |issue= 2 |pages= 191–7 |year= 1994 |pmid= 8194751 |doi=
*cite journal | author=Tokumitsu H, Soderling TR |title=Requirements for calcium and calmodulin in the calmodulin kinase activation cascade. |journal=J. Biol. Chem. |volume=271 |issue= 10 |pages= 5617–22 |year= 1996 |pmid= 8621423 |doi=
*cite journal | author=Chatila T, Anderson KA, Ho N, Means AR |title=A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR. |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21542–8 |year= 1996 |pmid= 8702940 |doi=
*cite journal | author=Melander Gradin H, Marklund U, Larsson N, "et al." |title=Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18. |journal=Mol. Cell. Biol. |volume=17 |issue= 6 |pages= 3459–67 |year= 1997 |pmid= 9154845 |doi=
*cite journal | author=Matsushita M, Nairn AC |title=Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase. |journal=J. Biol. Chem. |volume=273 |issue= 34 |pages= 21473–81 |year= 1998 |pmid= 9705275 |doi=
*cite journal | author=Anderson KA, Means RL, Huang QH, "et al." |title=Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31880–9 |year= 1998 |pmid= 9822657 |doi=
*cite journal | author=Hayashi Y, Nishio M, Naito Y, "et al." |title=Regulation of neuronal nitric-oxide synthase by calmodulin kinases. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20597–602 |year= 1999 |pmid= 10400690 |doi=
*cite journal | author=Blaeser F, Ho N, Prywes R, Chatila TA |title=Ca(2+)-dependent gene expression mediated by MEF2 transcription factors. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 197–209 |year= 2000 |pmid= 10617605 |doi=
*cite journal | author=Moreno CS, Park S, Nelson K, "et al." |title=WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5257–63 |year= 2000 |pmid= 10681496 |doi=
*cite journal | author=Komeima K, Hayashi Y, Naito Y, Watanabe Y |title=Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 28139–43 |year= 2000 |pmid= 10874031 |doi= 10.1074/jbc.M003198200
*cite journal | author=Wu JY, Ribar TJ, Cummings DE, "et al." |title=Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. |journal=Nat. Genet. |volume=25 |issue= 4 |pages= 448–52 |year= 2000 |pmid= 10932193 |doi= 10.1038/78153
*cite journal | author=Jang MK, Goo YH, Sohn YC, "et al." |title=Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20005–10 |year= 2001 |pmid= 11274168 |doi= 10.1074/jbc.M010211200
*cite journal | author=Hsu LS, Chen GD, Lee LS, "et al." |title=Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31113–23 |year= 2001 |pmid= 11395482 |doi= 10.1074/jbc.M011720200
*cite journal | author=Zhao X, Ito A, Kane CD, "et al." |title=The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 35042–8 |year= 2001 |pmid= 11470791 |doi= 10.1074/jbc.M105086200

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