LILRB1

LILRB1

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1, also known as LILRB1, is a human gene.

PBB_Summary
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summary_text = This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10859| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Hirohashi N, Nakao M, Kubo K, "et al." |title=A novel antigen (H47 Ag) on human lymphocytes involved in T cell activation. |journal=Cell. Immunol. |volume=152 |issue= 2 |pages= 371–82 |year= 1994 |pmid= 8258145 |doi= 10.1006/cimm.1993.1298
*cite journal | author=Samaridis J, Colonna M |title=Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. |journal=Eur. J. Immunol. |volume=27 |issue= 3 |pages= 660–5 |year= 1997 |pmid= 9079806 |doi=
*cite journal | author=Wagtmann N, Rojo S, Eichler E, "et al." |title=A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors. |journal=Curr. Biol. |volume=7 |issue= 8 |pages= 615–8 |year= 1997 |pmid= 9259559 |doi=
*cite journal | author=Cosman D, Fanger N, Borges L, "et al." |title=A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. |journal=Immunity |volume=7 |issue= 2 |pages= 273–82 |year= 1997 |pmid= 9285411 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Colonna M, Navarro F, Bellón T, "et al." |title=A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. |journal=J. Exp. Med. |volume=186 |issue= 11 |pages= 1809–18 |year= 1997 |pmid= 9382880 |doi=
*cite journal | author=Fanger NA, Cosman D, Peterson L, "et al." |title=The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. |journal=Eur. J. Immunol. |volume=28 |issue= 11 |pages= 3423–34 |year= 1998 |pmid= 9842885 |doi=
*cite journal | author=Navarro F, Llano M, Bellón T, "et al." |title=The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells. |journal=Eur. J. Immunol. |volume=29 |issue= 1 |pages= 277–83 |year= 1999 |pmid= 9933109 |doi=
*cite journal | author=Chapman TL, Heikeman AP, Bjorkman PJ |title=The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. |journal=Immunity |volume=11 |issue= 5 |pages= 603–13 |year= 2000 |pmid= 10591185 |doi=
*cite journal | author=Liu WR, Kim J, Nwankwo C, "et al." |title=Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on chromosome 19q13.4. |journal=Immunogenetics |volume=51 |issue= 8-9 |pages= 659–69 |year= 2000 |pmid= 10941837 |doi=
*cite journal | author=Chapman TL, Heikema AP, West AP, Bjorkman PJ |title=Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). |journal=Immunity |volume=13 |issue= 5 |pages= 727–36 |year= 2001 |pmid= 11114384 |doi=
*cite journal | author=Lepin EJ, Bastin JM, Allan DS, "et al." |title=Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors. |journal=Eur. J. Immunol. |volume=30 |issue= 12 |pages= 3552–61 |year= 2001 |pmid= 11169396 |doi=
*cite journal | author=Young NT, Canavez F, Uhrberg M, "et al." |title=Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex. |journal=Immunogenetics |volume=53 |issue= 4 |pages= 270–8 |year= 2001 |pmid= 11491530 |doi=
*cite journal | author=Saverino D, Merlo A, Bruno S, "et al." |title=Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells. |journal=J. Immunol. |volume=168 |issue= 1 |pages= 207–15 |year= 2002 |pmid= 11751964 |doi=
*cite journal | author=Bellón T, Kitzig F, Sayós J, López-Botet M |title=Mutational analysis of immunoreceptor tyrosine-based inhibition motifs of the Ig-like transcript 2 (CD85j) leukocyte receptor. |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3351–9 |year= 2002 |pmid= 11907092 |doi=
*cite journal | author=Nikolova M, Musette P, Bagot M, "et al." |title=Engagement of ILT2/CD85j in Sézary syndrome cells inhibits their CD3/TCR signaling. |journal=Blood |volume=100 |issue= 3 |pages= 1019–25 |year= 2002 |pmid= 12130517 |doi= 10.1182/blood-2001-12-0303
*cite journal | author=Willcox BE, Thomas LM, Chapman TL, "et al." |title=Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18. |journal=BMC Struct. Biol. |volume=2 |issue= |pages= 6 |year= 2003 |pmid= 12390682 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Achdout H, Arnon TI, Markel G, "et al." |title=Enhanced recognition of human NK receptors after influenza virus infection. |journal=J. Immunol. |volume=171 |issue= 2 |pages= 915–23 |year= 2003 |pmid= 12847262 |doi=

External links

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