PURA

Purine-rich element binding protein A, also known as PURA, is a human gene.

PBB_Summary
section_title =
summary_text = This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.cite web | title = Entrez Gene: PURA purine-rich element binding protein A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5813| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gallia GL, Johnson EM, Khalili K |title=Puralpha: a multifunctional single-stranded DNA- and RNA-binding protein. |journal=Nucleic Acids Res. |volume=28 |issue= 17 |pages= 3197–205 |year= 2000 |pmid= 10954586 |doi=
*cite journal | author=Peruzzi F, Gordon J, Darbinian N, Amini S |title=Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway. |journal=J. Neurovirol. |volume=8 Suppl 2 |issue= |pages= 91–6 |year= 2003 |pmid= 12491158 |doi= 10.1080/13550280290167885
*cite journal | author=Bergemann AD, Ma ZW, Johnson EM |title=Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein. |journal=Mol. Cell. Biol. |volume=12 |issue= 12 |pages= 5673–82 |year= 1992 |pmid= 1448097 |doi=
*cite journal | author=Bergemann AD, Johnson EM |title=The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication. |journal=Mol. Cell. Biol. |volume=12 |issue= 3 |pages= 1257–65 |year= 1992 |pmid= 1545807 |doi=
*cite journal | author=Johnson EM, Chen PL, Krachmarov CP, "et al." |title=Association of human Pur alpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pur alpha recognition element. |journal=J. Biol. Chem. |volume=270 |issue= 41 |pages= 24352–60 |year= 1995 |pmid= 7592647 |doi=
*cite journal | author=Ma ZW, Pejovic T, Najfeld V, "et al." |title=Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Pur alpha, to chromosome band 5q31. |journal=Cytogenet. Cell Genet. |volume=71 |issue= 1 |pages= 64–7 |year= 1995 |pmid= 7606931 |doi=
*cite journal | author=Chen NN, Chang CF, Gallia GL, "et al." |title=Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 4 |pages= 1087–91 |year= 1995 |pmid= 7862639 |doi=
*cite journal | author=Jurk M, Weissinger F, Lottspeich F, "et al." |title=Characterization of the single-strand-specific BPV-1 origin binding protein, SPSF I, as the HeLa Pur alpha factor. |journal=Nucleic Acids Res. |volume=24 |issue= 14 |pages= 2799–806 |year= 1996 |pmid= 8759014 |doi=
*cite journal | author=Krachmarov CP, Chepenik LG, Barr-Vagell S, "et al." |title=Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein Pur alpha. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 14112–7 |year= 1997 |pmid= 8943069 |doi=
*cite journal | author=Kelm RJ, Elder PK, Strauch AR, Getz MJ |title=Sequence of cDNAs encoding components of vascular actin single-stranded DNA-binding factor 2 establish identity to Puralpha and Purbeta. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26727–33 |year= 1997 |pmid= 9334258 |doi=
*cite journal | author=Thatikunta P, Sawaya BE, Denisova L, "et al." |title=Identification of a cellular protein that binds to Tat-responsive element of TGF beta-1 promoter in glial cells. |journal=J. Cell. Biochem. |volume=67 |issue= 4 |pages= 466–77 |year= 1998 |pmid= 9383706 |doi=
*cite journal | author=Itoh H, Wortman MJ, Kanovsky M, "et al." |title=Alterations in Pur(alpha) levels and intracellular localization in the CV-1 cell cycle. |journal=Cell Growth Differ. |volume=9 |issue= 8 |pages= 651–65 |year= 1998 |pmid= 9716182 |doi=
*cite journal | author=Gallia GL, Safak M, Khalili K |title=Interaction of the single-stranded DNA-binding protein Puralpha with the human polyomavirus JC virus early protein T-antigen. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32662–9 |year= 1999 |pmid= 9830007 |doi=
*cite journal | author=Safak M, Gallia GL, Khalili K |title=Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 2712–23 |year= 1999 |pmid= 10082537 |doi=
*cite journal | author=Kelm RJ, Cogan JG, Elder PK, "et al." |title=Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14238–45 |year= 1999 |pmid= 10318844 |doi=
*cite journal | author=Gallia GL, Darbinian N, Johnson EM, Khalili K |title=Self-association of Puralpha is mediated by RNA. |journal=J. Cell. Biochem. |volume=74 |issue= 3 |pages= 334–48 |year= 1999 |pmid= 10412036 |doi=
*cite journal | author=Tretiakova A, Steplewski A, Johnson EM, "et al." |title=Regulation of myelin basic protein gene transcription by Sp1 and Puralpha: evidence for association of Sp1 and Puralpha in brain. |journal=J. Cell. Physiol. |volume=181 |issue= 1 |pages= 160–8 |year= 1999 |pmid= 10457364 |doi= 10.1002/(SICI)1097-4652(199910)181:1<160::AID-JCP17>3.0.CO;2-H |doilabel=10.1002/(SICI)1097-4652(199910)181:1160::AID-JCP173.0.CO;2-H
*cite journal | author=Gallia GL, Darbinian N, Tretiakova A, "et al." |title=Association of HIV-1 Tat with the cellular protein, Puralpha, is mediated by RNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11572–7 |year= 1999 |pmid= 10500218 |doi=
*cite journal | author=Darbinian N, Gallia GL, Kundu M, "et al." |title=Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1. |journal=Oncogene |volume=18 |issue= 46 |pages= 6398–402 |year= 2000 |pmid= 10597240 |doi= 10.1038/sj.onc.1203011
*cite journal | author=Wortman MJ, Krachmarov CP, Kim JH, "et al." |title=Interaction of HIV-1 Tat with Puralpha in nuclei of human glial cells: characterization of RNA-mediated protein-protein binding. |journal=J. Cell. Biochem. |volume=77 |issue= 1 |pages= 65–74 |year= 2000 |pmid= 10679817 |doi=

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