Profilin 1

Profilin 1, also known as PFN1, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.cite web | title = Entrez Gene: PFN1 profilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5216| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Qualmann B, Kessels MM |title=Endocytosis and the cytoskeleton. |journal=Int. Rev. Cytol. |volume=220 |issue= |pages= 93–144 |year= 2003 |pmid= 12224553 |doi=
*cite journal | author=Kwiatkowski DJ, Aklog L, Ledbetter DH, Morton CC |title=Identification of the functional profilin gene, its localization to chromosome subband 17p13.3, and demonstration of its deletion in some patients with Miller-Dieker syndrome. |journal=Am. J. Hum. Genet. |volume=46 |issue= 3 |pages= 559–67 |year= 1990 |pmid= 1968707 |doi=
*cite journal | author=Ampe C, Markey F, Lindberg U, Vandekerckhove J |title=The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence. |journal=FEBS Lett. |volume=228 |issue= 1 |pages= 17–21 |year= 1988 |pmid= 3342873 |doi=
*cite journal | author=Kwiatkowski DJ, Bruns GA |title=Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis. |journal=J. Biol. Chem. |volume=263 |issue= 12 |pages= 5910–5 |year= 1988 |pmid= 3356709 |doi=
*cite journal | author=Gieselmann R, Kwiatkowski DJ, Janmey PA, Witke W |title=Distinct biochemical characteristics of the two human profilin isoforms. |journal=Eur. J. Biochem. |volume=229 |issue= 3 |pages= 621–8 |year= 1995 |pmid= 7758455 |doi=
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Metzler WJ, Constantine KL, Friedrichs MS, "et al." |title=Characterization of the three-dimensional solution structure of human profilin: 1H, 13C, and 15N NMR assignments and global folding pattern. |journal=Biochemistry |volume=32 |issue= 50 |pages= 13818–29 |year= 1994 |pmid= 8268157 |doi=
*cite journal | author=Schutt CE, Myslik JC, Rozycki MD, "et al." |title=The structure of crystalline profilin-beta-actin. |journal=Nature |volume=365 |issue= 6449 |pages= 810–6 |year= 1993 |pmid= 8413665 |doi= 10.1038/365810a0
*cite journal | author=Mahoney NM, Janmey PA, Almo SC |title=Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation. |journal=Nat. Struct. Biol. |volume=4 |issue= 11 |pages= 953–60 |year= 1997 |pmid= 9360613 |doi=
*cite journal | author=Mammoto A, Sasaki T, Asakura T, "et al." |title=Interactions of drebrin and gephyrin with profilin. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 1 |pages= 86–9 |year= 1998 |pmid= 9473484 |doi= 10.1006/bbrc.1997.8068
*cite journal | author=Bhargavi V, Chari VB, Singh SS |title=Phosphatidylinositol 3-kinase binds to profilin through the p85 alpha subunit and regulates cytoskeletal assembly. |journal=Biochem. Mol. Biol. Int. |volume=46 |issue= 2 |pages= 241–8 |year= 1998 |pmid= 9801792 |doi=
*cite journal | author=Suetsugu S, Miki H, Takenawa T |title=The essential role of profilin in the assembly of actin for microspike formation. |journal=EMBO J. |volume=17 |issue= 22 |pages= 6516–26 |year= 1999 |pmid= 9822597 |doi= 10.1093/emboj/17.22.6516
*cite journal | author=Miki H, Suetsugu S, Takenawa T |title=WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. |journal=EMBO J. |volume=17 |issue= 23 |pages= 6932–41 |year= 1999 |pmid= 9843499 |doi= 10.1093/emboj/17.23.6932
*cite journal | author=Mahoney NM, Rozwarski DA, Fedorov E, "et al." |title=Profilin binds proline-rich ligands in two distinct amide backbone orientations. |journal=Nat. Struct. Biol. |volume=6 |issue= 7 |pages= 666–71 |year= 1999 |pmid= 10404225 |doi= 10.1038/10722
*cite journal | author=Nunoi H, Yamazaki T, Tsuchiya H, "et al." |title=A heterozygous mutation of beta-actin associated with neutrophil dysfunction and recurrent infection. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 15 |pages= 8693–8 |year= 1999 |pmid= 10411937 |doi=
*cite journal | author=Murphy GA, Solski PA, Jillian SA, "et al." |title=Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth. |journal=Oncogene |volume=18 |issue= 26 |pages= 3831–45 |year= 1999 |pmid= 10445846 |doi= 10.1038/sj.onc.1202758
*cite journal | author=Harbeck B, Hüttelmaier S, Schluter K, "et al." |title=Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 30817–25 |year= 2000 |pmid= 10882740 |doi= 10.1074/jbc.M005066200
*cite journal | author=Boettner B, Govek EE, Cross J, Van Aelst L |title=The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 9064–9 |year= 2000 |pmid= 10922060 |doi=
*cite journal | author=Yayoshi-Yamamoto S, Taniuchi I, Watanabe T |title=FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages. |journal=Mol. Cell. Biol. |volume=20 |issue= 18 |pages= 6872–81 |year= 2000 |pmid= 10958683 |doi=
*cite journal | author=Mellon MB, Frank BT, Fang KC |title=Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving antibody-binding epitopes. |journal=J. Immunol. |volume=168 |issue= 1 |pages= 290–7 |year= 2002 |pmid= 11751973 |doi=

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