MHC class I polypeptide-related sequence A

MHC class I polypeptide-related sequence A
MHC class I polypeptide-related sequence A

PDB rendering based on 1b3j.
Identifiers
Symbols MICA; FLJ36918; FLJ60820; MGC111087; MGC21250; MIC-A; PERB11.1
External IDs OMIM600169 MGI2179989 HomoloGene125585 GeneCards: MICA Gene
RNA expression pattern
PBB GE MICA 205904 at tn.png
PBB GE MICA 205905 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 100507436 243864
Ensembl ENSG00000183214 n/a
UniProt Q29983 n/a
RefSeq (mRNA) NM_000247.1 XM_985890
RefSeq (protein) NP_000238.1 XP_990984
Location (UCSC) Chr c6_QBL:
31.5 – 31.52 Mb
n/a
PubMed search [1] [2]

MHC class I polypeptide-related sequence A is a protein that in humans is encoded by the MICA gene.[1]

MICA encodes the highly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells.[2]

See also

References

Further reading