5,10-methylenetetrahydromethanopterin reductase

In enzymology, a 5,10-methylenetetrahydromethanopterin reductase (EC number|1.5.99.11) is an enzyme that catalyzes the chemical reaction

:5-methyltetrahydromethanopterin + coenzyme F₄20 $ightleftharpoons$ 5,10-methylenetetrahydromethanopterin + reduced coenzyme F₄20

Thus, the two substrates of this enzyme are 5-methyltetrahydromethanopterin and coenzyme F420, whereas its two products are 5,10-methylenetetrahydromethanopterin and reduced coenzyme F420.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is 5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase. Other names in common use include 5,10-methylenetetrahydromethanopterin cyclohydrolase, N5,N10-methylenetetrahydromethanopterin reductase, methylene-H4MPT reductase, coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin, reductase, and N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase. This enzyme participates in folate biosynthesis.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|1Z69.

References

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External links

Gene Ontology (GO) codes