- MAP2
Microtubule-associated protein 2, also known as MAP2, is a human
gene .PBB_Summary
section_title =
summary_text = This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. MAP2 serves to stabilizemicrotubules (MT) growth by crosslinking MT withintermediate filaments and other MT. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described.cite web | title = Entrez Gene: MAP2 microtubule-associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4133| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Roses AD, Einstein G, Gilbert J, "et al." |title=Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. |journal=Ann. N. Y. Acad. Sci. |volume=777 |issue= |pages= 146–57 |year= 1996 |pmid= 8624078 |doi=10.1111/j.1749-6632.1996.tb34413.x
*cite journal | author=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227–30 |year= 1997 |pmid= 8997639 |doi=10.1007/BF02818986
*cite journal | author=Shafit-Zagardo B, Kalcheva N |title=Making sense of the multiple MAP-2 transcripts and their role in the neuron. |journal=Mol. Neurobiol. |volume=16 |issue= 2 |pages= 149–62 |year= 1999 |pmid= 9588626 |doi=10.1007/BF02740642
*cite journal | author=Liu Y, Saad RS, Shen SS, Silverman JF |title=Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms. |journal=Advances in anatomic pathology |volume=10 |issue= 2 |pages= 101–6 |year= 2003 |pmid= 12605092 |doi=10.1097/00125480-200303000-00005
*cite journal | author=Ainsztein AM, Purich DL |title=Cleavage of bovine brain microtubule-associated protein-2 by human immunodeficiency virus proteinase. |journal=J. Neurochem. |volume=59 |issue= 3 |pages= 874–80 |year= 1992 |pmid= 1494913 |doi=10.1111/j.1471-4159.1992.tb08325.x
*cite journal | author=Alberts MJ, Kandt RS, Pericak-Vance MA, "et al." |title=MspI RFLP for microtubule associated protein-2 (MAP2). |journal=Nucleic Acids Res. |volume=19 |issue= 4 |pages= 960 |year= 1991 |pmid= 1708129 |doi=10.1093/nar/19.4.960
*cite journal | author=Wallin M, Deinum J, Goobar L, Danielson UH |title=Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases. |journal=J. Gen. Virol. |volume=71 ( Pt 9) |issue= |pages= 1985–91 |year= 1990 |pmid= 2212989 |doi=10.1099/0022-1317-71-9-1985
*cite journal | author=Kosik KS, Orecchio LD, Bakalis S, "et al." |title=Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles. |journal=J. Neurochem. |volume=51 |issue= 2 |pages= 587–98 |year= 1988 |pmid= 2455776 |doi=10.1111/j.1471-4159.1988.tb01079.x
*cite journal | author=Dammerman M, Yen SH, Shafit-Zagardo B |title=Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles. |journal=J. Neurosci. Res. |volume=24 |issue= 4 |pages= 487–95 |year= 1990 |pmid= 2481044 |doi= 10.1002/jnr.490240405
*cite journal | author=Obar RA, Dingus J, Bayley H, Vallee RB |title=The RII subunit of cAMP-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A, 2B, and 2C. |journal=Neuron |volume=3 |issue= 5 |pages= 639–45 |year= 1990 |pmid= 2561973 |doi=10.1016/0896-6273(89)90274-2
*cite journal | author=Rubino HM, Dammerman M, Shafit-Zagardo B, Erlichman J |title=Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2. |journal=Neuron |volume=3 |issue= 5 |pages= 631–8 |year= 1990 |pmid= 2701845 |doi=10.1016/0896-6273(89)90273-0
*cite journal | author=Herrmann H, Wiche G |title=Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin. |journal=J. Biol. Chem. |volume=262 |issue= 3 |pages= 1320–5 |year= 1987 |pmid= 3027087 |doi=
*cite journal | author=Neve RL, Harris P, Kosik KS, "et al." |title=Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. |journal=Brain Res. |volume=387 |issue= 3 |pages= 271–80 |year= 1987 |pmid= 3103857 |doi=
*cite journal | author=Garner CC, Tucker RP, Matus A |title=Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites. |journal=Nature |volume=336 |issue= 6200 |pages= 674–7 |year= 1989 |pmid= 3200318 |doi= 10.1038/336674a0
*cite journal | author=Kalcheva N, Albala J, O'Guin K, "et al." |title=Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 24 |pages= 10894–8 |year= 1995 |pmid= 7479905 |doi=10.1073/pnas.92.24.10894
*cite journal | author=Takahashi M, Tomizawa K, Sato K, "et al." |title=A novel tau-tubulin kinase from bovine brain. |journal=FEBS Lett. |volume=372 |issue= 1 |pages= 59–64 |year= 1995 |pmid= 7556643 |doi=10.1016/0014-5793(95)00955-9
*cite journal | author=Kindler S, Garner CC |title=Four repeat MAP2 isoforms in human and rat brain. |journal=Brain Res. Mol. Brain Res. |volume=26 |issue= 1-2 |pages= 218–24 |year= 1995 |pmid= 7854050 |doi=10.1016/0169-328X(94)90093-0
*cite journal | author=Albala JS, Kalcheva N, Shafit-Zagardo B |title=Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2). |journal=Gene |volume=136 |issue= 1-2 |pages= 377–8 |year= 1994 |pmid= 8294038 |doi=10.1016/0378-1119(93)90502-T
*cite journal | author=Illenberger S, Drewes G, Trinczek B, "et al." |title=Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics. |journal=J. Biol. Chem. |volume=271 |issue= 18 |pages= 10834–43 |year= 1996 |pmid= 8631898 |doi=10.1074/jbc.271.18.10834PBB_Controls
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