Bradykinin receptor B2

Bradykinin receptor B2

Bradykinin receptor B2, also known as BDKRB2, is a bradykinin receptor, but also denotes the human gene encoding it.

Mechanism

The B2 receptor is a G protein-coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.

The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.cite journal | author = Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH | title = Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo | journal = Hypertension | volume = 37 | issue = 2 Part 2 | pages = 703–9 | year = 2001 | pmid = 11230360 | doi = | issn = | url = http://hyper.ahajournals.org/cgi/content/abstract/37/2/703 ]

Kallidin also signals through the B2 receptor.

Function

The 9 amino acid bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation.

Gene

Alternate start codons result in two isoforms of the protein.cite web | title = Entrez Gene: BDKRB2 bradykinin receptor B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=624| accessdate = ]

ee also

* Bradykinin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Duchêne J, Schanstra J, Cellier E, "et al." |title= [30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway] |journal=Néphrologie |volume=23 |issue= 1 |pages= 39–41 |year= 2002 |pmid= 11908480 |doi=
*cite journal | author=Ariza AC, Bobadilla NA, Halhali A |title= [Endothelin 1 and angiotensin II in preeeclampsia] |journal=Rev. Invest. Clin. |volume=59 |issue= 1 |pages= 48–56 |year= 2007 |pmid= 17569300 |doi=
*cite journal | author=Hess JF, Borkowski JA, Young GS, "et al." |title=Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 1 |pages= 260–8 |year= 1992 |pmid= 1314587 |doi=
*cite journal | author=Eggerickx D, Raspe E, Bertrand D, "et al." |title=Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 3 |pages= 1306–13 |year= 1992 |pmid= 1329734 |doi=
*cite journal | author=Kammerer S, Braun A, Arnold N, Roscher AA |title=The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 226–33 |year= 1995 |pmid= 7779089 |doi= 10.1006/bbrc.1995.1800
*cite journal | author=Braun A, Kammerer S, Böhme E, "et al." |title=Identification of polymorphic sites of the human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 234–40 |year= 1995 |pmid= 7779090 |doi= 10.1006/bbrc.1995.1801
*cite journal | author=Ma JX, Wang DZ, Ward DC, "et al." |title=Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. |journal=Genomics |volume=23 |issue= 2 |pages= 362–9 |year= 1995 |pmid= 7835885 |doi= 10.1006/geno.1994.1512
*cite journal | author=Powell SJ, Slynn G, Thomas C, "et al." |title=Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. |journal=Genomics |volume=15 |issue= 2 |pages= 435–8 |year= 1993 |pmid= 7916737 |doi= 10.1006/geno.1993.1084
*cite journal | author=Menke JG, Borkowski JA, Bierilo KK, "et al." |title=Expression cloning of a human B1 bradykinin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 34 |pages= 21583–6 |year= 1994 |pmid= 8063797 |doi=
*cite journal | author=Hess JF, Borkowski JA, Macneil T, "et al." |title=Differential pharmacology of cloned human and mouse B2 bradykinin receptors. |journal=Mol. Pharmacol. |volume=45 |issue= 1 |pages= 1–8 |year= 1994 |pmid= 8302267 |doi=
*cite journal | author=McIntyre P, Phillips E, Skidmore E, "et al." |title=Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity. |journal=Mol. Pharmacol. |volume=44 |issue= 2 |pages= 346–55 |year= 1993 |pmid= 8394991 |doi=
*cite journal | author=AbdAlla S, Godovac-Zimmermann J, Braun A, "et al." |title=Structure of the bradykinin B2 receptors' amino terminus. |journal=Biochemistry |volume=35 |issue= 23 |pages= 7514–9 |year= 1996 |pmid= 8652530 |doi= 10.1021/bi9601060
*cite journal | author=Isami S, Kishikawa H, Araki E, "et al." |title=Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway. |journal=Diabetologia |volume=39 |issue= 4 |pages= 412–20 |year= 1996 |pmid= 8777990 |doi=
*cite journal | author=Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL |title=Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms. |journal=Eur. J. Cell Biol. |volume=69 |issue= 3 |pages= 236–44 |year= 1996 |pmid= 8900488 |doi=
*cite journal | author=Soskic V, Nyakatura E, Roos M, "et al." |title=Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8539–45 |year= 1999 |pmid= 10085087 |doi=
*cite journal | author=Cassano G, Susca F, Lippe C, Guanti G |title=Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts. |journal=Gen. Pharmacol. |volume=32 |issue= 2 |pages= 239–44 |year= 1999 |pmid= 10188626 |doi=
*cite journal | author=Efremov R, Truong MJ, Darcissac EC, "et al." |title=Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function. |journal=Eur. J. Biochem. |volume=263 |issue= 3 |pages= 746–56 |year= 1999 |pmid= 10469138 |doi=
*cite journal | author=Marrero MB, Venema VJ, Ju H, "et al." |title=Endothelial nitric oxide synthase interactions with G-protein-coupled receptors. |journal=Biochem. J. |volume=343 Pt 2 |issue= |pages= 335–40 |year= 1999 |pmid= 10510297 |doi=
*cite journal | author=Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L |title=Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases. |journal=J. Cell. Biochem. |volume=76 |issue= 4 |pages= 658–73 |year= 2000 |pmid= 10653985 |doi=
*cite journal | author=Golser R, Gorren AC, Leber A, "et al." |title=Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5291–6 |year= 2000 |pmid= 10681501 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • Bradykinin receptor B1 — Bradykinin receptor B1, also known as BDKRB1, is a human gene.Bradykinin, a 9 amino acid peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G protein coupled receptors have… …   Wikipedia

  • Bradykinin receptor — protein Name = bradykinin receptor B1 caption = width = HGNCid = 1029 Symbol = BDKRB1 AltSymbols = EntrezGene = 623 OMIM = 600337 RefSeq = NM 000710 UniProt = P46663 PDB = ECnumber = Chromosome = 14 Arm = q Band = 32.1 LocusSupplementaryData = 32 …   Wikipedia

  • Bradykinin — Chembox new ImageFile=Bradykinin.png ImageSize= IUPACName= OtherNames= Section1= Chembox Identifiers CASNo=58 82 2 PubChem=6026 SMILES= MeSHName=Bradykinin Section2= Chembox Properties Formula=C50H73N15O11 MolarMass=1060.21 Appearance= Density=… …   Wikipedia

  • G protein-coupled receptor — G protein coupled receptors (GPCRs), also known as seven transmembrane domain receptors, 7TM receptors, heptahelical receptors, and G protein linked receptors (GPLR), comprise a large protein family of transmembrane receptors that sense molecules …   Wikipedia

  • Relaxin/insulin-like family peptide receptor 4 — Relaxin/insulin like family peptide receptor 4, also known as RXFP4, is a human gene.cite web | title = Entrez Gene: RXFP4 relaxin/insulin like family peptide receptor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • FSH-receptor — Follicle stimulating hormone receptor PDB rendering based on 1xwd …   Wikipedia

  • kappa Opioid receptor — Opioid receptor, kappa 1 Rendering based on PDB 2A0D …   Wikipedia

  • Opioid receptor — Opioid receptors are a group of G protein coupled receptors with opioids as ligands.[1][2][3] The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are 40% identical to somatostatin… …   Wikipedia

  • Nociceptin receptor — Opiate receptor like 1 Identifiers Symbols OPRL1; KOR 3; MGC34578; NOCIR; OOR; ORL1 External IDs …   Wikipedia

  • Tachykinin receptor 1 — Rendering based on PDB 2KS9 …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”