PIK3R1

PIK3R1
Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

PDB rendering based on 1bfi.
Identifiers
Symbols PIK3R1; GRB1; p85; p85-ALPHA
External IDs OMIM: 171833 HomoloGene: 7889 GeneCards: PIK3R1 Gene
RNA expression pattern
PBB GE PIK3R1 212240 s at tn.png
PBB GE PIK3R1 212249 at tn.png
PBB GE PIK3R1 212239 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5295 18708
Ensembl ENSG00000145675 ENSMUSG00000041417
UniProt P27986 n/a
RefSeq (mRNA) NM_001242466.1 n/a
RefSeq (protein) NP_001229395.1 n/a
Location (UCSC) Chr 5:
67.51 – 67.6 Mb		 Chr 13:
102.45 – 102.54 Mb
PubMed search [1] [2]

Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.[1]

Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms.[2]

Interactions

PIK3R1 has been shown to interact with EPH receptor A2,[3] KHDRBS1,[4][5] Lymphocyte cytosolic protein 2,[6] Janus kinase 2,[7] GAB2,[8][9] CD117,[10][11][12] BCAR1,[13] CD28,[14] SHB,[15] EZR,[16] PIK3CD,[17] GAB1,[18][19][20] HRAS,[21][22] TUBA1B,[23] CD7,[24][25] FCGR2A,[26][27] Grb2,[28][29] IRS2,[30][31][32][33] ADAM12,[34] TYRO3,[35] VAV1,[18][36] ERBB3,[37][38] Wiskott-Aldrich syndrome protein,[39] LTK,[40][41] PTK2,[42] Interleukin 1 receptor, type I,[43] CBLB,[44][45] Erythropoietin receptor,[36][46] Linker of activated T cells,[47] Cbl gene,[48][49][50] IRS1[51][52][53][33] and CENTG1.[54]

References

  1. ^ Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, Bernardi F, Rooke L, Waterfield MD (May 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene 7 (4): 789–93. PMID 1314371. 
  2. ^ "Entrez Gene: PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5295. 
  3. ^ Pandey, A; Lazar D F, Saltiel A R, Dixit V M (Dec. 1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity". J. Biol. Chem. (UNITED STATES) 269 (48): 30154–7. ISSN 0021-9258. PMID 7982920. 
  4. ^ Sánchez-Margalet, V; Najib S (Oct. 2001). "Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling". Mol. Cell. Endocrinol. (Ireland) 183 (1-2): 113–21. doi:10.1016/S0303-7207(01)00587-1. ISSN 0303-7207. PMID 11604231. 
  5. ^ Shen, Z; Batzer A, Koehler J A, Polakis P, Schlessinger J, Lydon N B, Moran M F (Aug. 1999). "Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src". Oncogene (ENGLAND) 18 (33): 4647–53. doi:10.1038/sj.onc.1203079. ISSN 0950-9232. PMID 10467411. 
  6. ^ Shim, Eun Kyung; Moon Chang Suk, Lee Gi Yeon, Ha Yun Jung, Chae Suhn-Kee, Lee Jong Ran (Sep. 2004). "Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase". FEBS Lett. (Netherlands) 575 (1-3): 35–40. doi:10.1016/j.febslet.2004.07.090. ISSN 0014-5793. PMID 15388330. 
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  10. ^ De Sepulveda, P; Okkenhaug K, Rose J L, Hawley R G, Dubreuil P, Rottapel R (Feb. 1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. (ENGLAND) 18 (4): 904–15. doi:10.1093/emboj/18.4.904. ISSN 0261-4189. PMC 1171183. PMID 10022833. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171183. 
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  24. ^ Lee, D M; Patel D D, Pendergast A M, Haynes B F (Aug. 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". Int. Immunol. (ENGLAND) 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. ISSN 0953-8178. PMID 8918688. 
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  54. ^ Ye, K; Hurt K J, Wu F Y, Fang M, Luo H R, Hong J J, Blackshaw S, Ferris C D, Snyder S H (Dec. 2000). "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N". Cell (UNITED STATES) 103 (6): 919–30. doi:10.1016/S0092-8674(00)00195-1. ISSN 0092-8674. PMID 11136977. 

Further reading

  • Benito M, Valverde AM, Lorenzo M (1996). "IGF-I: a mitogen also involved in differentiation processes in mammalian cells.". Int. J. Biochem. Cell Biol. 28 (5): 499–510. doi:10.1016/1357-2725(95)00168-9. PMID 8697095. 
  • Snapper SB, Rosen FS (1999). "The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization.". Annu. Rev. Immunol. 17: 905–29. doi:10.1146/annurev.immunol.17.1.905. PMID 10358777. 
  • Katada T, Kurosu H, Okada T, et al. (1999). "Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors.". Chem. Phys. Lipids 98 (1-2): 79–86. doi:10.1016/S0009-3084(99)00020-1. PMID 10358930. 
  • Zhang W, Samelson LE (2000). "The role of membrane-associated adaptors in T cell receptor signalling.". Semin. Immunol. 12 (1): 35–41. doi:10.1006/smim.2000.0205. PMID 10723796. 
  • Greenway AL, Holloway G, McPhee DA, et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". J. Biosci. 28 (3): 323–35. doi:10.1007/BF02970151. PMID 12734410. 
  • Leavitt SA, SchOn A, Klein JC, et al. (2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.". Curr. Protein Pept. Sci. 5 (1): 1–8. doi:10.2174/1389203043486955. PMID 14965316. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726. 

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  • Фосфоинозитид-3-киназа — Фосфоинозитид 3 киназы, или фосфатидилинозитол 3 киназы (КФ 2.7.1; англ. Phosphoinositide 3 kinases, PI 3 kinases, PI3Ks) семейство ферментов, фосфорилирующих фосфатидилинозитол в положении 3D инозитольного кольца. Существует 3 класса… …   Википедия

  • Фосфатидилинозитол-3-киназа — Фосфоинозитид 3 киназы, или фосфатидилинозитол 3 киназы (КФ 2.7.1; англ. Phosphoinositide 3 kinases, PI 3 kinases, PI3Ks) семейство ферментов, фосфорилирующих фосфатидилинозитол в положении 3D инозитольного кольца. Существует 3 класса… …   Википедия

  • Ezrin — PDB rendering based on 1ni2 …   Wikipedia

  • CD7 — Антиген T лимфоцитов CD7 Обозначения Символы CD7; GP40, LEU 9, Tp40, TP41 Entrez Gene …   Википедия

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